{"id":"W2029549287","doi":"10.1158/1538-7445.am2011-2562","title":"Abstract 2562: Efficacy of RG7204 (PLX4032), a selective BRAFV600E inhibitor, in combination with pegylated interferon alpha-2a (Pegasys), paclitaxel, carboplatin, and anti-VEGF MAb B20-4.1 in the LOX-IMVI human melanoma xenograft model","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Workplace Health, Safety and Compensation Commission","funders":"","keywords":"Carboplatin; Medicine; Dacarbazine; Combination therapy; Bevacizumab; Melanoma; Pharmacology; Paclitaxel; Regimen; Oncology; Chemotherapy; Internal medicine; Cancer research; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002147487,0.0008680256,0.0007150819,0.0003197473,0.0001754616,0.0003123132,0.0003367767,0.0005203446,0.002865237],"category_scores_gemma":[0.0001247009,0.0002045613,0.000456617,0.0001720691,0.0002756718,0.0003083663,0.0001039749,0.001183755,0.000706784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003649147,"about_ca_system_score_gemma":0.0005080129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001458206,"about_ca_topic_score_gemma":0.001667404,"domain_scores_codex":[0.9998841,0.00002651051,0.000008597696,0.0000214097,0.00002222864,0.00003716048],"domain_scores_gemma":[0.9998994,0.00001302625,0.00001797351,0.00001183863,0.000009279584,0.00004848116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007899227,0.003590141,0.0002657058,0.0001331451,0.00003564429,0.0001283502,0.0000228603,0.0004978051,0.9782419,0.0001007585,0.001138545,0.007945915],"study_design_scores_gemma":[0.0017912,0.04803862,0.004493438,0.00001495548,0.000103777,0.0004522265,0.00002471095,0.00186248,0.9399623,0.0000591828,0.003177117,0.00002004703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934679,0.0017375,0.0004095876,0.0002553891,0.0001912814,0.0001277815,0.0008937543,0.0001921246,0.002724701],"genre_scores_gemma":[0.9878684,0.001309395,0.001256025,0.0001192017,0.00007427685,0.0001315831,0.001795276,0.00004494944,0.007400905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002865237,"threshold_uncertainty_score":0.009585142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07699664315181229,"score_gpt":0.3615442279514269,"score_spread":0.2845475847996146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}