{"id":"W2029549287","doi":"10.1158/1538-7445.am2011-2562","title":"Abstract 2562: Efficacy of RG7204 (PLX4032), a selective BRAFV600E inhibitor, in combination with pegylated interferon alpha-2a (Pegasys), paclitaxel, carboplatin, and anti-VEGF MAb B20-4.1 in the LOX-IMVI human melanoma xenograft model","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Workplace Health, Safety and Compensation Commission","funders":"","keywords":"Carboplatin; Medicine; Dacarbazine; Combination therapy; Bevacizumab; Melanoma; Pharmacology; Paclitaxel; Regimen; Oncology; Chemotherapy; Internal medicine; Cancer research; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006430834,0.0002351355,0.0003238109,0.0001891489,0.0001747968,0.00005264726,0.0004566209,0.0002089949,0.0001921761],"category_scores_gemma":[0.0000733132,0.0001906851,0.00004728347,0.0007810278,0.0004104373,0.0001866837,0.0001226198,0.001068773,0.000003215571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002712294,"about_ca_system_score_gemma":0.0002381685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003404611,"about_ca_topic_score_gemma":0.001840698,"domain_scores_codex":[0.9978917,0.00008366234,0.0004720005,0.0005414881,0.0005037183,0.0005074751],"domain_scores_gemma":[0.9986948,0.0002697764,0.0001581042,0.0005100955,0.0002671058,0.000100146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007753769,0.001344389,0.0313211,0.0005259394,0.00008215942,0.0000319182,0.01566802,0.0001287722,0.9476706,0.0007021146,0.0002765034,0.001473094],"study_design_scores_gemma":[0.004687511,0.0002620674,0.06717986,0.0007269783,0.00002384768,0.00001487045,0.002979468,0.001100981,0.9209682,0.001605411,0.00006816317,0.0003825844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896205,0.0003006957,0.000008331747,0.0002042567,0.000006920278,0.0004591166,0.00005416122,0.00002871706,0.009317284],"genre_scores_gemma":[0.9991818,0.00008024998,0.00003509652,0.00001216025,0.0000459626,0.0003738111,0.00006015352,0.00003623235,0.0001745088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03585877,"threshold_uncertainty_score":0.777591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07699664315181229,"score_gpt":0.3615442279514269,"score_spread":0.2845475847996146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}