{"id":"W2029563076","doi":"10.1001/jamaneurol.2014.1491","title":"Effects of Multiple Genetic Loci on Age at Onset in Late-Onset Alzheimer Disease","year":2014,"lang":"en","type":"review","venue":"JAMA Neurology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":196,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"National Human Genome Research Institute; National Institute of Mental Health; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Center for Advancing Translational Sciences; Medical Research Council; Hersenstichting; National Cancer Institute; Stichting MS Research; Newcastle University; Broad Institute; Wellcome Trust; National Institute of Environmental Health Sciences; Northern California Institute for Research and Education; University of Washington; Alzheimer's Disease Neuroimaging Initiative; National Center for Research Resources; F. Hoffmann-La Roche; Vanderbilt University; Children's Hospital of Philadelphia; National Institute of Neurological Disorders and Stroke; University of Pittsburgh; U.S. Department of Veterans Affairs; Office of Research and Development; Massachusetts General Hospital; Medpace; Parkinson's UK; Brigham and Women's Hospital; Washington University in St. Louis; GlaxoSmithKline; Pfizer; Elan; Novartis; Universitat de Barcelona; Rush University; Synarc; Dana Foundation; FONDATION ALZHEIMER; Alzheimer's Association; Alzheimer's Research Trust; Eli Lilly and Company; Bristol-Myers Squibb; AstraZeneca; Eisai; Howard Hughes Medical Institute","keywords":"Apolipoprotein E; Disease; Alzheimer's disease; Age of onset; Single-nucleotide polymorphism; Genotype; Genome-wide association study; Medicine; Genetics; Biology; Internal medicine; Oncology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01014124,0.001376888,0.001516876,0.001942897,0.000451989,0.001564261,0.00104971,0.00117701,0.001326046],"category_scores_gemma":[0.01691819,0.0005401176,0.005176611,0.00232924,0.0007466649,0.000709823,0.0008162456,0.00111167,0.000114106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004607862,"about_ca_system_score_gemma":0.0006577427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006222752,"about_ca_topic_score_gemma":0.009228103,"domain_scores_codex":[0.9933902,0.003606855,0.0006262024,0.001498975,0.0006430955,0.0002345848],"domain_scores_gemma":[0.980875,0.0129493,0.003526139,0.001617651,0.0006120937,0.0004197903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004579681,0.0001267996,0.9213726,0.0007727354,0.04970359,0.0005701465,0.0001717484,0.001899856,0.002747535,0.0004136478,0.00026905,0.01737261],"study_design_scores_gemma":[0.0005020785,0.0009702944,0.949803,0.0003841796,0.04018072,0.0007301379,0.0001017083,0.00356891,0.001020339,0.00184085,0.0008595184,0.00003827506],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9362245,0.05448572,0.005988579,0.0007842256,0.0001406496,0.00005338425,0.001018637,0.0001215664,0.001182754],"genre_scores_gemma":[0.9943257,0.003033326,0.00191312,0.0001170562,0.00008085705,0.00002568984,0.0002563361,0.0000201991,0.000227649],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.01014124,"threshold_uncertainty_score":0.05363262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01932002397331389,"score_gpt":0.2895879727166101,"score_spread":0.2702679487432962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}