{"id":"W2029564171","doi":"10.1016/j.biochi.2011.02.015","title":"General oxidative stress during doxorubicin-induced cardiotoxicity in rats: Absence of cardioprotection and low antioxidant efficiency of alpha-lipoic acid","year":2011,"lang":"en","type":"article","venue":"Biochimie","topic":"Biochemical Acid Research Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Conseil régional de Bourgogne-Franche-Comté; Agence Universitaire de la Francophonie","keywords":"Cardiotoxicity; Oxidative stress; Chemistry; Doxorubicin; Antioxidant; Pharmacology; Ascorbic acid; Cardioprotection; In vivo; Malondialdehyde; Contractility; Endocrinology; Internal medicine; Biochemistry; Toxicity; Medicine; Chemotherapy; Ischemia; Biology; Food science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002676121,0.000830948,0.0006095202,0.0004901729,0.0002745421,0.0002852081,0.0002386045,0.0005485495,0.001293633],"category_scores_gemma":[0.0003140943,0.0004564605,0.0003070412,0.0003010044,0.0009126546,0.0008702356,0.0002582532,0.001022284,0.0002244007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003643948,"about_ca_system_score_gemma":0.0004258363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009523882,"about_ca_topic_score_gemma":0.001463414,"domain_scores_codex":[0.9998691,0.00001959515,0.00001376955,0.00003755539,0.00001875701,0.00004117275],"domain_scores_gemma":[0.9995095,0.00004408542,0.0001548001,0.00008611445,0.00005021881,0.0001553656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00929793,0.0001517567,0.00153346,0.00008557583,0.00003177471,0.0001722226,0.00007856303,0.0001083621,0.9864027,0.0001586144,0.0000469221,0.001932131],"study_design_scores_gemma":[0.0001880573,0.003019009,0.02050823,0.00001479023,0.0001681839,0.0003202555,0.0001252765,0.000647739,0.9741281,0.0002543326,0.000602156,0.00002385708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962819,0.001249568,0.001584424,0.0001056116,0.00004351117,0.00002375276,0.0002583177,0.00005246092,0.0004005111],"genre_scores_gemma":[0.9963824,0.000925748,0.0006621057,0.00006604855,0.00002367419,0.00004764631,0.0003723286,0.00001958284,0.001500479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001293633,"threshold_uncertainty_score":0.004327595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01554887027588131,"score_gpt":0.2473747448800303,"score_spread":0.231825874604149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}