{"id":"W2029564171","doi":"10.1016/j.biochi.2011.02.015","title":"General oxidative stress during doxorubicin-induced cardiotoxicity in rats: Absence of cardioprotection and low antioxidant efficiency of alpha-lipoic acid","year":2011,"lang":"en","type":"article","venue":"Biochimie","topic":"Biochemical Acid Research Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Conseil régional de Bourgogne-Franche-Comté; Agence Universitaire de la Francophonie","keywords":"Cardiotoxicity; Oxidative stress; Chemistry; Doxorubicin; Antioxidant; Pharmacology; Ascorbic acid; Cardioprotection; In vivo; Malondialdehyde; Contractility; Endocrinology; Internal medicine; Biochemistry; Toxicity; Medicine; Chemotherapy; Ischemia; Biology; Food science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002105838,0.0001775937,0.0003153703,0.00009808221,0.00005238848,0.000004737276,0.0001754036,0.0001555375,0.000003382605],"category_scores_gemma":[0.0001308449,0.0001550561,0.00009803128,0.0002018346,0.0002998567,0.000006920162,0.0002601676,0.0001352848,5.61583e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002124917,"about_ca_system_score_gemma":0.00004585981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003761628,"about_ca_topic_score_gemma":0.00004828417,"domain_scores_codex":[0.9987032,0.00009344745,0.0003041616,0.0004063169,0.0002086642,0.0002841692],"domain_scores_gemma":[0.9993719,0.000008127433,0.0001317128,0.000286292,0.0001334185,0.00006855952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000205086,0.0001266095,0.009902646,0.0001678299,0.00007708841,0.000003919352,0.000164301,0.000004609471,0.9890442,0.00000964565,0.000004634064,0.0002893574],"study_design_scores_gemma":[0.0004612522,0.0003337048,0.09981497,0.00007872743,0.000008771031,0.000006870423,0.0001181315,0.00001606702,0.8990008,0.00001425751,0.000001874318,0.000144549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979184,0.001262372,0.0001346931,0.00001048964,0.00005198603,0.0003427887,0.00005007742,0.000007079373,0.0002220686],"genre_scores_gemma":[0.9989855,0.0004668273,0.0004122821,0.000005361946,0.00006602691,0.00002605069,0.000007065914,0.00001241227,0.0000184358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09004345,"threshold_uncertainty_score":0.6323004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01554887027588131,"score_gpt":0.2473747448800303,"score_spread":0.231825874604149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}