{"id":"W2029597892","doi":"10.4161/cbt.24596","title":"Identification of repurposed small molecule drugs for chordoma therapy","year":2013,"lang":"en","type":"article","venue":"Cancer Biology & Therapy","topic":"Bone Tumor Diagnosis and Treatments","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; Medical Center, University of Pittsburgh; National Institutes of Health; University of Calgary","keywords":"Chordoma; Staurosporine; Pharmacology; Medicine; Cancer research; Internal medicine; Biology; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009813105,0.0001350512,0.0003038081,0.00005694782,0.00004341049,0.000007214897,0.00008885287,0.00009519471,0.0002756265],"category_scores_gemma":[0.000009681139,0.00009571741,0.0001338266,0.00009210249,0.00009995867,0.0000290425,0.000006372376,0.00005057561,0.00001619796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004342595,"about_ca_system_score_gemma":0.0000615188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003191131,"about_ca_topic_score_gemma":0.000006363449,"domain_scores_codex":[0.999168,0.00003709267,0.0002879905,0.0002714149,0.00004683754,0.0001886005],"domain_scores_gemma":[0.9991962,0.00006059564,0.000180425,0.0003167213,0.00019067,0.00005539151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004835972,0.0004603901,0.05649221,0.00001654506,0.0004349644,7.111256e-7,0.0003899035,4.340217e-7,0.7337213,0.0003145025,0.001108921,0.2065766],"study_design_scores_gemma":[0.008904143,0.001410646,0.196378,0.0000400247,0.00005090086,0.000003419517,0.0000760096,0.00004470359,0.7787479,0.001506795,0.01267325,0.0001641828],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838163,0.01215069,0.00008576917,0.00201329,0.0002002029,0.001558032,0.00003067376,0.00003377951,0.0001112582],"genre_scores_gemma":[0.986967,0.008958693,0.0001795121,0.001141853,0.0001073752,0.001917048,0.00007183783,0.0000251177,0.0006316061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2064124,"threshold_uncertainty_score":0.3903243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03344090278317161,"score_gpt":0.32340432743414,"score_spread":0.2899634246509684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}