{"id":"W2029600440","doi":"10.1021/bi051601b","title":"Characterization of Functional Heme Domains from Soluble Guanylate Cyclase","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Eye Institute","keywords":"Heme; Hemeprotein; Chemistry; Autoxidation; Ligand (biochemistry); Protein subunit; Cofactor; Stereochemistry; Soluble guanylyl cyclase; Nitric oxide; Guanylate cyclase; Biophysics; Enzyme; Biochemistry; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001525416,0.0002068435,0.0001374576,0.0001438138,0.0001197662,0.0001752579,0.0001911488,0.0002122469,0.0006208805],"category_scores_gemma":[0.000283764,0.00007371889,0.0001502138,0.0001504833,0.0001456498,0.0001142071,0.000131072,0.0003422634,0.0002117294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002826807,"about_ca_system_score_gemma":0.0001420475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008945023,"about_ca_topic_score_gemma":0.0008792928,"domain_scores_codex":[0.9999028,0.00001474058,0.00000804548,0.00002019627,0.00003520334,0.00001910019],"domain_scores_gemma":[0.9998349,0.00003536049,0.0000390794,0.00002015951,0.00003362275,0.00003687789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002847402,0.000009684813,0.0002438409,0.00001810245,0.00000170658,0.00002859721,0.00001338971,0.00003993274,0.9989324,0.00004908125,0.00001948017,0.0006153289],"study_design_scores_gemma":[0.0000253291,0.000217909,0.02226489,0.00001580368,0.00001744721,0.0007509679,0.00006000709,0.001941015,0.9674736,0.00008602327,0.007139157,0.000007841188],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963176,0.0005578757,0.002000961,0.00007396648,0.00001128186,0.00001828248,0.0005305962,0.00001565817,0.0004736391],"genre_scores_gemma":[0.9892124,0.0004190444,0.004028562,0.00006298498,0.00001169944,0.00002916928,0.00437529,0.0000223583,0.00183853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008945023,"threshold_uncertainty_score":0.002077043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01052659832735168,"score_gpt":0.2281297948402566,"score_spread":0.217603196512905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}