{"id":"W2029600440","doi":"10.1021/bi051601b","title":"Characterization of Functional Heme Domains from Soluble Guanylate Cyclase","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Eye Institute","keywords":"Heme; Hemeprotein; Chemistry; Autoxidation; Ligand (biochemistry); Protein subunit; Cofactor; Stereochemistry; Soluble guanylyl cyclase; Nitric oxide; Guanylate cyclase; Biophysics; Enzyme; Biochemistry; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004956885,0.00008772877,0.0001433877,0.00002309923,0.00002312837,0.000004434404,0.00003724447,0.00009501086,0.0006566238],"category_scores_gemma":[0.0000413737,0.00008173307,0.00006445007,0.00007417126,0.00003161426,0.00003780577,0.00001909515,0.00007644744,0.00007969738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004038267,"about_ca_system_score_gemma":0.00006154559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000130194,"about_ca_topic_score_gemma":5.265494e-7,"domain_scores_codex":[0.9994002,0.000005962241,0.0001667978,0.0001550269,0.0001548708,0.0001171615],"domain_scores_gemma":[0.9995732,0.00002622039,0.00007267679,0.0002012737,0.00004772219,0.00007888165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001322592,0.000112752,0.002295639,0.00005178589,0.00003640094,0.000005356589,0.00001896607,0.000001888349,0.9950966,0.000005290168,0.0008261573,0.001416938],"study_design_scores_gemma":[0.001162324,0.00002326842,0.01092748,0.00005113846,0.00004698561,0.00001352625,0.0000103548,0.000267519,0.9835051,0.00001837025,0.003898609,0.00007533125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969502,0.0001091688,0.0004199627,0.0004001257,0.00010333,0.0000753127,0.0000419435,0.0000409614,0.001859015],"genre_scores_gemma":[0.9941454,0.00002648269,0.0006029878,0.0002760317,0.0008429913,0.00000726009,0.0005251876,0.00001262816,0.003561031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01159148,"threshold_uncertainty_score":0.7189571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01052659832735168,"score_gpt":0.2281297948402566,"score_spread":0.217603196512905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}