{"id":"W2029622368","doi":"10.1128/aac.05175-11","title":"A Novel Target-Specific, Salt-Resistant Antimicrobial Peptide against the Cariogenic Pathogen Streptococcus mutans","year":2011,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Marine Biosciences; Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Atlantic Canada Opportunities Agency; China Scholarship Council; Canadian Institutes of Health Research; Dalhousie University","keywords":"Streptococcus mutans; Streptococcus gordonii; Microbiology; Streptococcus sanguinis; Peptide; Antimicrobial; Pathogen; Chemistry; Saliva; Mutant; Biofilm; Antimicrobial peptides; Biology; Bacteria; Biochemistry; Streptococcaceae; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002886586,0.0006943392,0.0006915333,0.0001396747,0.0009617346,0.0001376682,0.0006940284,0.0004213623,0.001506029],"category_scores_gemma":[0.00001216569,0.0005165471,0.0003785582,0.0002931402,0.0009486786,0.0002505071,0.0002305405,0.0005467022,0.0002609313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006082066,"about_ca_system_score_gemma":0.0001097616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007092734,"about_ca_topic_score_gemma":0.0001130238,"domain_scores_codex":[0.9971704,0.0001352616,0.0006897368,0.0008835203,0.00008785498,0.001033236],"domain_scores_gemma":[0.9986771,0.00006676211,0.000350218,0.0006782268,0.0001428322,0.00008490578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005035878,0.000513576,0.002468683,0.00003194708,0.000452809,0.00002346382,0.002752248,0.000003280115,0.8876039,0.0003527144,0.1022645,0.003029299],"study_design_scores_gemma":[0.004751131,0.0002706841,0.0245064,0.0001705148,0.0001240246,0.0001892549,0.0008020247,0.000006613904,0.5303947,0.00008167195,0.4374714,0.001231641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991362,0.0003839625,0.0007626456,0.001428773,0.001157545,0.001007748,0.0007991607,0.0001958963,0.002902267],"genre_scores_gemma":[0.9825891,0.002645973,0.001258071,0.01010373,0.0002350434,0.00002786057,0.0002872002,0.0001308044,0.002722249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3572092,"threshold_uncertainty_score":0.9997286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02084977372598796,"score_gpt":0.2159914364613027,"score_spread":0.1951416627353148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}