{"id":"W2029639001","doi":"10.1016/s0006-2952(03)00544-6","title":"Targeting oxidative stress-related diseases: organochalcogen catalysts as redox sensitizers","year":2003,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Organic Chemistry Cycloaddition Reactions","field":"Chemistry","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Alzheimer Society; Wellcome Trust","keywords":"Oxidative stress; Redox; Reactive oxygen species; Pro-oxidant; Chemistry; Transcription factor; Glutathione; Oxidative phosphorylation; Programmed cell death; Cell biology; In vitro; Biochemistry; Cell; Biophysics; Biology; Enzyme; Apoptosis; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00007689725,0.0003685379,0.0003524087,0.00005519086,0.0001877129,0.00002398472,0.0002671205,0.0004064225,0.03232039],"category_scores_gemma":[0.0006218851,0.0004090139,0.0001622815,0.0003389794,0.0003112246,0.00009212758,0.0001102601,0.0005555009,0.0007236781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003455383,"about_ca_system_score_gemma":0.0002424164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001647894,"about_ca_topic_score_gemma":1.047218e-7,"domain_scores_codex":[0.9978516,0.00006879171,0.0004956127,0.0007301759,0.0002601049,0.0005937192],"domain_scores_gemma":[0.9985455,0.0002700811,0.0002374105,0.000321248,0.0001527914,0.0004729916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003263387,0.0002490769,0.00006761345,0.00005124133,0.0002167596,0.0001037569,0.00006992277,0.000007422368,0.7984235,0.00004697511,0.2007174,0.00001362513],"study_design_scores_gemma":[0.001299178,0.00000969164,0.000005784223,0.00001966662,0.0002679668,0.0001459608,0.0004812226,0.00003219464,0.9819769,0.0002483064,0.01509077,0.0004224133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.971884,0.0008630643,0.00001021262,0.0005095095,0.0004494094,0.0001510559,0.0006432848,0.0004428814,0.02504666],"genre_scores_gemma":[0.9956167,0.00007652341,0.0001217905,0.0003345576,0.0003590588,0.00004858076,0.001495007,0.00006769493,0.00188003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1856267,"threshold_uncertainty_score":0.9998361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005398025138145422,"score_gpt":0.2547619771524844,"score_spread":0.249363952014339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}