{"id":"W2029645617","doi":"10.1523/jneurosci.5109-14.2015","title":"A Human Monoclonal IgG That Binds Aβ Assemblies and Diverse Amyloids Exhibits Anti-Amyloid Activities<i>In Vitro</i>and<i>In Vivo</i>","year":2015,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"National Institute on Aging","keywords":"In vivo; Amyloid (mycology); Epitope; P3 peptide; In vitro; Antibody; Genetically modified mouse; Monoclonal antibody; Amyloidosis; Chemistry; Amyloid precursor protein; Alzheimer's disease; Molecular biology; Biology; Biochemistry; Immunology; Transgene; Medicine; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002423199,0.000517862,0.0002514679,0.0002685835,0.000136765,0.0002807367,0.0004678228,0.0005601916,0.001349513],"category_scores_gemma":[0.0001857884,0.0001238977,0.0003499293,0.0002654886,0.0002192622,0.0001384937,0.0001949594,0.0003718937,0.0006414836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005572381,"about_ca_system_score_gemma":0.0002586663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00179547,"about_ca_topic_score_gemma":0.001198522,"domain_scores_codex":[0.9998295,0.00002221124,0.00001235206,0.00004715717,0.00004569509,0.00004298265],"domain_scores_gemma":[0.9998952,0.00002316158,0.00002015928,0.00001150461,0.00002329563,0.00002673469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000886769,0.00007322968,0.0008213451,0.00007825732,0.00001492435,0.00009701847,0.00001156876,0.00006942344,0.9900997,0.0001177379,0.0002474724,0.008280647],"study_design_scores_gemma":[0.0001000003,0.001517553,0.01757783,0.00003189038,0.00008838197,0.002744343,0.00002483398,0.00116066,0.959922,0.0001326091,0.01668553,0.00001452115],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9572376,0.01545288,0.01630307,0.0003930612,0.0001544205,0.0002302086,0.0007665874,0.0007418083,0.008720368],"genre_scores_gemma":[0.9877858,0.002859913,0.005187615,0.0003560847,0.0000715266,0.00006888441,0.001094757,0.00002644603,0.002548992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00179547,"threshold_uncertainty_score":0.004514575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0677638856548015,"score_gpt":0.3310860877948072,"score_spread":0.2633222021400057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}