{"id":"W2029660372","doi":"10.1074/jbc.m110.163709","title":"MyoD Directly Up-regulates Premyogenic Mesoderm Factors during Induction of Skeletal Myogenesis in Stem Cells","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Western University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research","keywords":"MyoD; Myogenin; Myogenesis; MYF5; Myogenic regulatory factors; PITX2; PAX3; Biology; Mesoderm; Skeletal muscle; Myocyte; MyoD Protein; Cell biology; Molecular biology; Genetics; Endocrinology; Transcription factor; Homeobox; Embryonic stem cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001213908,0.0003364378,0.0002485484,0.0003994243,0.0001548846,0.0002724103,0.0001529943,0.0001590758,0.001499054],"category_scores_gemma":[0.00008723523,0.0002926744,0.0002756529,0.0001838841,0.0002177156,0.0001157702,0.0003400724,0.0004763047,0.0006987493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004539099,"about_ca_system_score_gemma":0.0002365324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005678753,"about_ca_topic_score_gemma":0.002013355,"domain_scores_codex":[0.9998093,0.00002173419,0.00002495595,0.00004224621,0.00006422841,0.0000375211],"domain_scores_gemma":[0.9999001,0.00002786341,0.00002240644,0.00001271394,0.00001003653,0.00002685564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003686487,0.00001340018,0.000143158,0.00002573143,0.000002172339,0.0000311467,0.000008395374,0.0000153314,0.9990909,0.00004831702,0.00003803874,0.0005464842],"study_design_scores_gemma":[0.000009037059,0.00007250683,0.004291032,0.000004269314,0.000007766199,0.00006600803,0.00001040936,0.0003278352,0.9922995,0.00001509109,0.002894884,0.000001668398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852788,0.003726543,0.003859333,0.0001745901,0.00007863811,0.00007121808,0.001866215,0.0001876284,0.0047569],"genre_scores_gemma":[0.9759889,0.002443352,0.006431288,0.0002080902,0.000033761,0.00008827184,0.003848383,0.00008975311,0.01086826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001499054,"threshold_uncertainty_score":0.005014837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01158203033419264,"score_gpt":0.2275734192131085,"score_spread":0.2159913888789159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}