{"id":"W2029660372","doi":"10.1074/jbc.m110.163709","title":"MyoD Directly Up-regulates Premyogenic Mesoderm Factors during Induction of Skeletal Myogenesis in Stem Cells","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Western University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research","keywords":"MyoD; Myogenin; Myogenesis; MYF5; Myogenic regulatory factors; PITX2; PAX3; Biology; Mesoderm; Skeletal muscle; Myocyte; MyoD Protein; Cell biology; Molecular biology; Genetics; Endocrinology; Transcription factor; Homeobox; Embryonic stem cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001919531,0.0001778531,0.0003110438,0.00003667696,0.00003939867,0.000005991666,0.0002580278,0.0004915845,0.00009253965],"category_scores_gemma":[0.00008132721,0.000131804,0.000243211,0.00009302329,0.00018246,0.000007630613,0.00008206182,0.0003321512,6.782114e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001201128,"about_ca_system_score_gemma":0.00005743491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000445921,"about_ca_topic_score_gemma":0.000004542445,"domain_scores_codex":[0.9989142,0.00005233479,0.0004775014,0.000231851,0.000106314,0.0002178099],"domain_scores_gemma":[0.9992161,0.00003092286,0.0003773575,0.0001875275,0.00009555778,0.00009247181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000252264,0.0001322313,0.01784979,0.00004081035,0.0000590097,0.000002660046,0.00002289402,0.0000361468,0.9810793,0.000001273859,0.00002516305,0.000498466],"study_design_scores_gemma":[0.0005617149,0.0001498846,0.05838649,0.00001280179,0.00001390043,0.00003319718,0.0001455773,0.000002248941,0.9403836,0.00004658058,0.0001244506,0.0001395693],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991501,0.0004129946,0.00000520767,0.00002215435,0.0002319232,0.00005493514,0.000009872139,0.000004922139,0.0001078869],"genre_scores_gemma":[0.999406,0.000199146,0.00005993641,0.000009592967,0.0001832899,0.000002452753,0.00001372383,0.000009862391,0.0001160197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04069571,"threshold_uncertainty_score":0.5374812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01158203033419264,"score_gpt":0.2275734192131085,"score_spread":0.2159913888789159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}