{"id":"W2029743370","doi":"10.1210/me.2003-0431","title":"Activation of Adenosine Triphosphate-Sensitive Potassium Channels by Acyl Coenzyme A Esters Involves Multiple Phosphatidylinositol 4,5-Bisphosphate-Interacting Residues","year":2003,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Allosteric regulation; Biology; Phosphatidylinositol 4,5-bisphosphate; Adenosine triphosphate; Potassium channel; Biochemistry; Biophysics; Cell biology; Coenzyme A; Salt bridge; Phosphatidylinositol; Signal transduction; Enzyme; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001400702,0.0003390721,0.0003641786,0.0001365754,0.0001276762,0.00003155429,0.0001669183,0.000249674,0.00005282503],"category_scores_gemma":[0.0005987046,0.0003580102,0.0001695143,0.0002265459,0.0001516672,0.00002677574,0.00008327306,0.0001850756,0.00001469379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004915404,"about_ca_system_score_gemma":0.0000722995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001035332,"about_ca_topic_score_gemma":0.000008275125,"domain_scores_codex":[0.9978877,0.0002218171,0.0005098291,0.0006217493,0.0002274571,0.0005314773],"domain_scores_gemma":[0.9987566,0.00007526907,0.0003697943,0.0003874945,0.0002953168,0.0001155313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005250498,0.0001827925,0.001668155,0.00003289694,0.0001671545,0.00002138742,0.0001682413,0.0009082895,0.9877858,0.0008092872,0.006942523,0.0007884642],"study_design_scores_gemma":[0.001847952,0.0004104381,0.0003781623,0.00003736068,0.0000344225,0.00004911358,0.0003598607,0.0005602859,0.9735293,0.00004673159,0.02242592,0.0003204514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9594598,0.001446515,0.03591162,0.0005051707,0.001372123,0.0005517598,0.00003126065,0.00005633056,0.0006654707],"genre_scores_gemma":[0.9971168,0.0001467653,0.0008088982,0.0005324563,0.0001002691,0.00005624082,0.0004441424,0.00005612733,0.0007382781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03765707,"threshold_uncertainty_score":0.9998872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01074941469536974,"score_gpt":0.2415322605670705,"score_spread":0.2307828458717008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}