{"id":"W2029743370","doi":"10.1210/me.2003-0431","title":"Activation of Adenosine Triphosphate-Sensitive Potassium Channels by Acyl Coenzyme A Esters Involves Multiple Phosphatidylinositol 4,5-Bisphosphate-Interacting Residues","year":2003,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Allosteric regulation; Biology; Phosphatidylinositol 4,5-bisphosphate; Adenosine triphosphate; Potassium channel; Biochemistry; Biophysics; Cell biology; Coenzyme A; Salt bridge; Phosphatidylinositol; Signal transduction; Enzyme; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001302274,0.000329031,0.0003295769,0.00008998919,0.0002173099,0.0004912684,0.0003522915,0.0005340066,0.0005653689],"category_scores_gemma":[0.0002281101,0.0001461353,0.0005270073,0.0001300569,0.0003622682,0.0005117484,0.0002516379,0.0004879157,0.0004280077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003877244,"about_ca_system_score_gemma":0.0002692657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003514919,"about_ca_topic_score_gemma":0.0003849816,"domain_scores_codex":[0.9998767,0.00001762411,0.00001753087,0.00003183715,0.00003604695,0.00002021833],"domain_scores_gemma":[0.9998912,0.00002157515,0.00004959368,0.00001070559,0.000009709847,0.00001733414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001721737,0.00002896639,0.0006237382,0.00004509584,0.000008958627,0.0001791241,0.00001361224,0.0005147118,0.9957641,0.0004769217,0.00003110329,0.00214159],"study_design_scores_gemma":[0.00005854347,0.0002412167,0.004605301,0.000008919829,0.00002314409,0.001227294,0.00004112414,0.006662438,0.9851143,0.000563105,0.001439032,0.00001555284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893692,0.0007724946,0.008351564,0.0001779818,0.00003444342,0.00002137947,0.0001075355,0.00007812041,0.001087342],"genre_scores_gemma":[0.9939768,0.0009121734,0.004421528,0.00006630278,0.00000752138,0.00001649961,0.000123799,0.000009473359,0.0004658848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005653689,"threshold_uncertainty_score":0.00281316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01074941469536974,"score_gpt":0.2415322605670705,"score_spread":0.2307828458717008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}