{"id":"W2029753295","doi":"10.1074/jbc.m313764200","title":"Development of Protein-based Inhibitors of the Proprotein of Convertase SKI-1/S1P","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Proprotein convertase; Furin; Proprotein Convertases; Sterol regulatory element-binding protein; Glycoprotein; Biology; Biochemistry; Endoplasmic reticulum; Mutant; Transcription factor; Amino acid; Chemistry; Cell biology; Lipoprotein; Enzyme; Cholesterol; LDL receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002674446,0.0007265855,0.0004176356,0.0003293589,0.00010552,0.0002913912,0.0005076083,0.0003351302,0.00104814],"category_scores_gemma":[0.0001345005,0.0002240986,0.0003856445,0.00019753,0.0001514297,0.0001888988,0.0001787177,0.000856764,0.0005193878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002730273,"about_ca_system_score_gemma":0.0002566418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004163903,"about_ca_topic_score_gemma":0.0006589674,"domain_scores_codex":[0.9998597,0.00002152815,0.00001689282,0.00002674532,0.00004585214,0.00002919672],"domain_scores_gemma":[0.9998991,0.00002056746,0.00002916918,0.000008990554,0.0000150433,0.00002706619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002754352,0.0001828818,0.0000681977,0.00008212736,0.00001954756,0.00003830856,0.00001019478,0.0002143736,0.9946991,0.0001239803,0.00007707982,0.004208785],"study_design_scores_gemma":[0.00008078694,0.0012452,0.0006022896,0.000005672724,0.00003422483,0.000154732,0.000005077529,0.0007483148,0.993491,0.00001746559,0.003610743,0.000004487579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9729509,0.01290572,0.008630645,0.0001701823,0.0001166796,0.0002889992,0.0008594691,0.0002220866,0.003855171],"genre_scores_gemma":[0.9735543,0.008814609,0.01067439,0.00007632541,0.00004268287,0.0002340413,0.002087014,0.00003871799,0.004477979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00104814,"threshold_uncertainty_score":0.003506422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01013864699929304,"score_gpt":0.2246264358661902,"score_spread":0.2144877888668972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}