{"id":"W2029775714","doi":"10.1016/j.bmc.2013.08.057","title":"Antiproliferative, antiandrogenic and cytotoxic effects of novel caffeic acid derivatives in LNCaP human androgen-dependent prostate cancer cells","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Moncton; Institut National de la Recherche Scientifique","funders":"Natural Sciences and Engineering Research Council of Canada; New Brunswick Innovation Foundation; Fondation de la recherche en santé du Nouveau-Brunswick; Armand-Frappier Foundation","keywords":"LNCaP; Caffeic acid phenethyl ester; Chemistry; Caffeic acid; Cytotoxic T cell; Prostate cancer; Cell growth; Androgen; Viability assay; Endocrinology; Pharmacology; Cancer research; Biochemistry; Internal medicine; Cell; Biology; Cancer; In vitro; Medicine; Hormone; Antioxidant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001561426,0.0003269619,0.0002689537,0.0003478245,0.0002091122,0.0001326017,0.0002486935,0.0002009712,0.001415303],"category_scores_gemma":[0.00009001296,0.0001131578,0.0003947372,0.0002671176,0.0001796818,0.0001932283,0.0001159528,0.0003364405,0.0001753867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000136331,"about_ca_system_score_gemma":0.0002184557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001607524,"about_ca_topic_score_gemma":0.003508776,"domain_scores_codex":[0.9999458,0.0000105375,0.00000530066,0.000008555333,0.00001244072,0.00001746292],"domain_scores_gemma":[0.9999518,0.00001053224,0.000008363626,0.000005888447,0.000009108845,0.00001436169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008444235,0.0001288476,0.0002048287,0.0001939211,0.00003175626,0.000154478,0.00006343905,0.0002198147,0.9930702,0.00009689033,0.0001153807,0.004876015],"study_design_scores_gemma":[0.00007748626,0.002111997,0.004714483,0.00001428481,0.0001111588,0.0002520198,0.00004880984,0.0003310995,0.9889921,0.00002997735,0.003305176,0.00001137734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909856,0.006498053,0.0004577073,0.00008347815,0.00004160838,0.00002144354,0.0003924548,0.00003748615,0.001482147],"genre_scores_gemma":[0.9947292,0.002809212,0.0005134434,0.00004110867,0.0000166548,0.000008550157,0.0004370658,0.000005201743,0.001439527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001607524,"threshold_uncertainty_score":0.004734695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008823055580098212,"score_gpt":0.257026926539713,"score_spread":0.2482038709596148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}