{"id":"W2029775714","doi":"10.1016/j.bmc.2013.08.057","title":"Antiproliferative, antiandrogenic and cytotoxic effects of novel caffeic acid derivatives in LNCaP human androgen-dependent prostate cancer cells","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Moncton; Institut National de la Recherche Scientifique","funders":"Natural Sciences and Engineering Research Council of Canada; New Brunswick Innovation Foundation; Fondation de la recherche en santé du Nouveau-Brunswick; Armand-Frappier Foundation","keywords":"LNCaP; Caffeic acid phenethyl ester; Chemistry; Caffeic acid; Cytotoxic T cell; Prostate cancer; Cell growth; Androgen; Viability assay; Endocrinology; Pharmacology; Cancer research; Biochemistry; Internal medicine; Cell; Biology; Cancer; In vitro; Medicine; Hormone; Antioxidant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002154605,0.0003930815,0.0008456896,0.0001172277,0.00008687699,0.00001675415,0.0001579622,0.0002464346,0.000524433],"category_scores_gemma":[0.0001245249,0.0002929958,0.00007936263,0.0003578742,0.0004735988,0.00009413592,0.00009267776,0.0004771504,0.000004755049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001068884,"about_ca_system_score_gemma":0.0002073835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002567508,"about_ca_topic_score_gemma":0.00001418417,"domain_scores_codex":[0.9977643,0.00003574801,0.0006086434,0.0005559445,0.0005445876,0.0004908079],"domain_scores_gemma":[0.9987971,0.00007508472,0.000235871,0.0003591138,0.0001743611,0.0003585375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001069513,0.0003941265,0.04324268,0.001854039,0.0001612538,0.0001266735,0.0008673921,3.734526e-7,0.9526359,0.000002972253,0.0001936365,0.0004140196],"study_design_scores_gemma":[0.007599809,0.0004036195,0.04310774,0.001369791,0.0001787285,0.000245428,0.0009213345,0.00008221563,0.9457945,0.000009261745,0.00003570076,0.0002519368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883713,0.009788436,0.00002646043,0.0004404121,0.0001359788,0.001020035,0.00001393963,0.00003979307,0.0001636678],"genre_scores_gemma":[0.9972845,0.001384043,0.000136504,0.0002664077,0.0003124212,0.00009967665,0.00002439536,0.00005049917,0.0004415052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00891327,"threshold_uncertainty_score":0.9999522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008823055580098212,"score_gpt":0.257026926539713,"score_spread":0.2482038709596148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}