{"id":"W2029777559","doi":"10.1021/bi300410d","title":"The Nucleotide Sequence, DNA Damage Location, and Protein Stoichiometry Influence the Base Excision Repair Outcome at CAG/CTG Repeats","year":2012,"lang":"en","type":"article","venue":"Biochemistry","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute on Aging; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; National Institutes of Health; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Centre National de la Recherche Scientifique; Université de Strasbourg; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Muscular Dystrophy Association","keywords":"Sequence (biology); Nucleotide; DNA; DNA repair; Nucleotide excision repair; Base pair; Nucleic acid sequence; Genetics; Chemistry; Biology; Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004521755,0.0002369681,0.0001264083,0.00003237304,0.0008830225,0.000104641,0.0004996668,0.0000655269,0.00002539128],"category_scores_gemma":[0.004326693,0.0001479425,0.00006912212,0.0004735514,0.0006332945,0.0001547155,0.0003966159,0.0001805187,0.00005212891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008102422,"about_ca_system_score_gemma":0.00008250026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001095223,"about_ca_topic_score_gemma":0.000002710577,"domain_scores_codex":[0.9979935,0.0002226489,0.0003363602,0.0005572448,0.0004613015,0.0004288927],"domain_scores_gemma":[0.9979711,0.0003572361,0.0001826213,0.001148053,0.0001095955,0.0002313583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002325362,0.00004216307,0.02023965,0.00004623886,0.000002856633,0.000006510399,0.00006763179,0.00001191208,0.9784809,0.0001003547,0.0008538052,0.0001247609],"study_design_scores_gemma":[0.0001383719,0.00001659933,0.05540619,0.00002504697,0.00001335414,0.00002609541,0.00007845514,0.00009796541,0.942595,0.00003515957,0.001390344,0.000177395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977785,0.000447371,0.00001372391,0.00062823,0.000113492,0.0004321147,0.00003679313,0.0001086664,0.0004411374],"genre_scores_gemma":[0.9952933,0.00003169715,0.0001058084,0.000810209,0.0001245277,0.00009388533,0.000004457802,0.00002679014,0.003509366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03588584,"threshold_uncertainty_score":0.6791584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03389629459332603,"score_gpt":0.2876970951996267,"score_spread":0.2538008006063006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}