{"id":"W2029780546","doi":"10.1242/dev.115147","title":"Proteasome regulation of the chromodomain protein MRG-1 controls the balance between proliferative fate and differentiation in the<i>C. elegans</i>germ line","year":2015,"lang":"en","type":"article","venue":"Development","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Cell biology; Proteasome; Cell fate determination; Cell growth; Stem cell; Cellular differentiation; Caenorhabditis elegans; Protein degradation; Genetics; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005853664,0.0001224382,0.0001280872,0.00001714022,0.00008915918,0.00002822962,0.0002107532,0.00007328534,0.000001253616],"category_scores_gemma":[0.00007528371,0.00006614442,0.00002303209,0.00007333266,0.00008450244,0.000004924842,0.00008254436,0.00009160177,9.679517e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002336045,"about_ca_system_score_gemma":0.0001300605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001249731,"about_ca_topic_score_gemma":0.00007141888,"domain_scores_codex":[0.9989797,0.0002090697,0.0002491739,0.0001882287,0.0002271225,0.0001466658],"domain_scores_gemma":[0.9994782,0.00001187908,0.0001499785,0.0002438665,0.0000875432,0.00002852531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001121839,0.0001426057,0.1078149,0.00006800429,0.0001051388,6.329726e-7,0.01571755,0.0002901911,0.8721838,0.000388205,0.0002081718,0.002968608],"study_design_scores_gemma":[0.0007995713,0.00009041864,0.4975064,0.00003037295,0.00001236804,0.000002353227,0.0001594344,0.0002122988,0.4984283,0.0007287563,0.001912708,0.00011699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924183,0.0001649723,0.004697205,0.001222174,0.00003544932,0.001402127,0.000006429283,0.000003857017,0.00004952229],"genre_scores_gemma":[0.9986274,0.000007320692,0.0007191448,0.0001506878,0.00009234808,0.0001746102,0.00004350331,0.000009548692,0.0001754408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3896915,"threshold_uncertainty_score":0.2697291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0164118140259936,"score_gpt":0.2268027809449411,"score_spread":0.2103909669189475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}