{"id":"W2029786576","doi":"10.1016/j.molcel.2008.08.025","title":"Mus81-Dependent Double-Strand DNA Breaks at In Vivo-Generated Cruciform Structures in S. cerevisiae","year":2008,"lang":"en","type":"article","venue":"Molecular Cell","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Canada Research Chairs; Hospital for Sick Children; University of Toronto; University of New Brunswick","funders":"National Cancer Institute","keywords":"Biology; Cruciform; Holliday junction; DNA; DNA supercoil; Genetics; Chromatin; Palindrome; Transposase; Nuclease; Palindromic sequence; Cell biology; Tn3 transposon; Inverted repeat; DNA repair; Transposable element; DNA replication; Gene; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002464844,0.0003213085,0.0001833536,0.0001609339,0.0002277137,0.0004197445,0.0001777116,0.0002452977,0.0010749],"category_scores_gemma":[0.0002218756,0.0002231434,0.0002309295,0.0001132257,0.000223702,0.0001961078,0.0002307453,0.0004693173,0.0004778484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000452329,"about_ca_system_score_gemma":0.0002100699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001124222,"about_ca_topic_score_gemma":0.001408893,"domain_scores_codex":[0.9998907,0.00002373259,0.00001367279,0.00002179412,0.00002693541,0.0000230991],"domain_scores_gemma":[0.9997967,0.00003961781,0.00005027441,0.00004367246,0.00002805613,0.00004170006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006944407,0.00001355496,0.0001879917,0.00002522426,0.000004780403,0.00007305156,0.00003033731,0.0001850505,0.9982501,0.0003467002,0.00003473251,0.0007788942],"study_design_scores_gemma":[0.000007483271,0.00005208145,0.001265568,0.000003560733,0.000007093287,0.0001349692,0.00004452044,0.0006571884,0.9967055,0.00008405379,0.001033543,0.000004442321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997346,0.0003782634,0.001281193,0.00004010954,0.00001778028,0.000006818059,0.00007926527,0.00005588711,0.00079458],"genre_scores_gemma":[0.9970306,0.0001596158,0.000761016,0.00001366396,0.000002355131,0.00000376435,0.0002172338,0.00003149971,0.001780045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001124222,"threshold_uncertainty_score":0.003595948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008931498735569303,"score_gpt":0.215263691895216,"score_spread":0.2063321931596467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}