{"id":"W2029786576","doi":"10.1016/j.molcel.2008.08.025","title":"Mus81-Dependent Double-Strand DNA Breaks at In Vivo-Generated Cruciform Structures in S. cerevisiae","year":2008,"lang":"en","type":"article","venue":"Molecular Cell","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Canada Research Chairs; Hospital for Sick Children; University of Toronto; University of New Brunswick","funders":"National Cancer Institute","keywords":"Biology; Cruciform; Holliday junction; DNA; DNA supercoil; Genetics; Chromatin; Palindrome; Transposase; Nuclease; Palindromic sequence; Cell biology; Tn3 transposon; Inverted repeat; DNA repair; Transposable element; DNA replication; Gene; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001581868,0.0003266697,0.000294559,0.0001426455,0.00006583896,0.0000205202,0.0003143653,0.0003403089,0.0001638032],"category_scores_gemma":[0.00001152484,0.0003345103,0.0001389128,0.000203818,0.00006331362,0.000006155028,0.0002077198,0.0001815274,0.00002272164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008873496,"about_ca_system_score_gemma":0.00009460739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000216048,"about_ca_topic_score_gemma":0.0006213791,"domain_scores_codex":[0.9980441,0.0000868289,0.0004025915,0.0006807333,0.0002799418,0.0005057636],"domain_scores_gemma":[0.9991254,0.000004533936,0.00009476293,0.0005913483,0.00004813001,0.0001358157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000233328,0.00009282491,0.001628814,0.00002930701,0.00001808417,0.0005356211,0.00009767589,0.0008199698,0.9960189,0.00004614169,0.0002687976,0.0002105353],"study_design_scores_gemma":[0.003166077,0.0001414046,0.001102502,0.00001234462,0.00001036084,0.00009611695,0.00002356693,0.0000909279,0.9900605,0.00008183037,0.004835218,0.0003791409],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894679,0.001317141,0.0002911812,0.00003306222,0.0001395768,0.0004289731,0.00002384591,0.00002506413,0.008273317],"genre_scores_gemma":[0.9969137,0.0002218087,0.0006275258,0.0002784089,0.00005538399,0.00003819025,0.0001216873,0.00006161002,0.001681664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007445882,"threshold_uncertainty_score":0.9999107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008931498735569303,"score_gpt":0.215263691895216,"score_spread":0.2063321931596467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}