{"id":"W2029812913","doi":"10.1046/j.1460-9568.2003.02887.x","title":"Inhibition of neurokinin‐1–substance P receptor and prostanoid activity prevents and reverses the development of morphine tolerance <i>in vivo</i> and the morphine‐induced increase in CGRP expression in cultured dorsal root ganglion neurons","year":2003,"lang":"en","type":"article","venue":"European Journal of Neuroscience","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Calcitonin gene-related peptide; Morphine; Substance P; Pharmacology; Opioid; Neuropeptide; Drug tolerance; Nimesulide; Receptor antagonist; Opioid receptor; Internal medicine; (+)-Naloxone; Endocrinology; Antagonist; Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001020389,0.0004524944,0.0004340597,0.0001898207,0.0001166705,0.0002182456,0.00028037,0.000221451,0.001171987],"category_scores_gemma":[0.0001239813,0.0001492526,0.0003405614,0.000151666,0.0002646456,0.0002096279,0.0001724156,0.0008888079,0.0003639954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002059077,"about_ca_system_score_gemma":0.0004274405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007559248,"about_ca_topic_score_gemma":0.001784442,"domain_scores_codex":[0.9998658,0.0000120192,0.00001736982,0.00001562687,0.00003921763,0.00004994269],"domain_scores_gemma":[0.999907,0.000008325762,0.00002929681,0.000009608213,0.00000791806,0.00003790758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000271517,0.00008583032,0.00008628196,0.00007129821,0.000007836258,0.00006090531,0.0000112477,0.00002956273,0.9972184,0.00005372042,0.00003493275,0.002068541],"study_design_scores_gemma":[0.00006131596,0.001897169,0.007284631,0.00001292128,0.00002963062,0.0003020228,0.00003145988,0.0005465152,0.9883602,0.00004005724,0.001426537,0.000007673136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951327,0.002222219,0.0010294,0.00008191523,0.0000378096,0.00003076198,0.0002037044,0.00008596547,0.001175397],"genre_scores_gemma":[0.9922249,0.002378331,0.001695717,0.0000655893,0.00002893976,0.00008249479,0.0006206215,0.00001835669,0.002885032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001171987,"threshold_uncertainty_score":0.003920674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01944055626317732,"score_gpt":0.2451510722266796,"score_spread":0.2257105159635023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}