{"id":"W2029812913","doi":"10.1046/j.1460-9568.2003.02887.x","title":"Inhibition of neurokinin‐1–substance P receptor and prostanoid activity prevents and reverses the development of morphine tolerance <i>in vivo</i> and the morphine‐induced increase in CGRP expression in cultured dorsal root ganglion neurons","year":2003,"lang":"en","type":"article","venue":"European Journal of Neuroscience","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Calcitonin gene-related peptide; Morphine; Substance P; Pharmacology; Opioid; Neuropeptide; Drug tolerance; Nimesulide; Receptor antagonist; Opioid receptor; Internal medicine; (+)-Naloxone; Endocrinology; Antagonist; Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001569239,0.000145343,0.0002938495,0.0001301635,0.00007143905,0.00001633917,0.00009318397,0.00001838337,0.000001339796],"category_scores_gemma":[0.0005406172,0.00008324296,0.00002578697,0.0003829544,0.0001900077,0.0002375319,0.00005173533,0.000266938,6.635022e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002188592,"about_ca_system_score_gemma":0.0000573938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005941598,"about_ca_topic_score_gemma":0.00001685211,"domain_scores_codex":[0.9979392,0.0008555771,0.0005005293,0.0002410082,0.0003066682,0.0001569858],"domain_scores_gemma":[0.9991866,0.0001107123,0.0004406618,0.0001421275,0.00004836922,0.00007153526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000742922,0.000231193,0.01217228,0.00003532749,0.000001544598,0.0001718315,0.001745343,0.00002387914,0.9841594,0.00001274018,0.000005831214,0.0006976658],"study_design_scores_gemma":[0.006140079,0.0004476725,0.6753095,0.0007483801,0.0000142529,0.0002199957,0.0001391874,0.000138108,0.3166524,0.00004108421,0.0000620514,0.00008733948],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998907,0.0002143929,0.000107393,0.000220039,0.00008596405,0.000399939,0.00000348502,0.000002459036,0.00005937464],"genre_scores_gemma":[0.9989036,0.0002212589,0.0007221624,0.0001097961,0.000008329378,0.00000336108,1.891558e-7,0.00001104873,0.00002026339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6675071,"threshold_uncertainty_score":0.3394549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01944055626317732,"score_gpt":0.2451510722266796,"score_spread":0.2257105159635023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}