{"id":"W2029827764","doi":"10.1021/bi200854q","title":"Two ZnF-UBP Domains in Isopeptidase T (USP5)","year":2012,"lang":"en","type":"article","venue":"Biochemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health; Wellcome Trust","keywords":"Ubiquitin; Chemistry; Residue (chemistry); Enzyme; Peptide; Allosteric regulation; Substrate (aquarium); Cysteine; Active site; Deubiquitinating enzyme; Biochemistry; Hydrolase; Hydrolysis; Stereochemistry; Cell biology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001322599,0.0003401025,0.0002387941,0.0001449808,0.0001582295,0.0002121395,0.0003715398,0.0003897933,0.0004316],"category_scores_gemma":[0.0001564338,0.0001409183,0.0003132531,0.0001549955,0.0002292143,0.0002554841,0.0002686073,0.0004056213,0.0003569679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005080529,"about_ca_system_score_gemma":0.0001910416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000544469,"about_ca_topic_score_gemma":0.0004616067,"domain_scores_codex":[0.9998732,0.00002473972,0.00001176174,0.00004070481,0.00002946832,0.00002018798],"domain_scores_gemma":[0.9999325,0.00000883031,0.00002616013,0.000008204062,0.000005441006,0.00001884423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003459133,0.00005914291,0.001088828,0.00006117506,0.000013322,0.0003656595,0.00001280282,0.0003083978,0.9923579,0.0004282415,0.00006273009,0.004895828],"study_design_scores_gemma":[0.00007671332,0.0003505494,0.009509545,0.00001276552,0.00004595994,0.002781347,0.00002680221,0.002973799,0.9788681,0.0002020427,0.005141387,0.00001100812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818894,0.002200366,0.01471685,0.00008286381,0.00002988567,0.00004592499,0.0002681701,0.00006390871,0.0007026751],"genre_scores_gemma":[0.9885265,0.0004400627,0.009227956,0.00004713448,0.000007151476,0.00003089498,0.0006790168,0.000006655269,0.001034618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000544469,"threshold_uncertainty_score":0.00368619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01216857544034292,"score_gpt":0.2623643941607088,"score_spread":0.2501958187203658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}