{"id":"W2029869170","doi":"10.1093/eurheartj/ehr372","title":"Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies","year":2011,"lang":"en","type":"review","venue":"European Heart Journal","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Heart Research Centre; University of Ottawa","funders":"National Center for Research Resources; National Heart, Lung, and Blood Institute; National Institute on Aging; U.S. Public Health Service; National Institutes of Health; Erasmus Universiteit Rotterdam; Universität Ulm; National Center for Advancing Translational Sciences; National Human Genome Research Institute; Münchner Zentrum für Gesundheitswissenschaften; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; GlaxoSmithKline; Erasmus Medisch Centrum; Cedars-Sinai Medical Center; Deutsche Forschungsgemeinschaft; European Commission; National Institute of Diabetes and Digestive and Kidney Diseases; ZonMw; School of Medicine, Boston University; National Institute of Neurological Disorders and Stroke; Bundesministerium für Bildung und Forschung","keywords":"Lipoprotein-associated phospholipase A2; Medicine; Genome-wide association study; Coronary heart disease; Meta-analysis; Phospholipase A2; Epidemiology; Internal medicine; Disease; Cardiology; Genetics; Bioinformatics; Lipoprotein; Genotype; Gene; Single-nucleotide polymorphism; Cholesterol; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002824535,0.0004952857,0.002415192,0.0003330954,0.0003556741,0.00006423811,0.0001633093,0.0001966201,0.00002311475],"category_scores_gemma":[0.001735837,0.0003919251,0.0006796216,0.00039585,0.0001482561,0.00002080803,0.0001683233,0.0006873379,0.000001387388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002540528,"about_ca_system_score_gemma":0.000206026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008323351,"about_ca_topic_score_gemma":0.0001800339,"domain_scores_codex":[0.9919593,0.006140905,0.0007842209,0.0004486303,0.000360606,0.0003063268],"domain_scores_gemma":[0.9966998,0.0007558996,0.00152217,0.0003777135,0.0004629425,0.0001814704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"observational","study_design_scores_codex":[0.001383135,0.002436311,0.06717733,0.005560993,0.8956082,0.000524436,0.003485484,0.003438904,0.00286716,0.000008928192,0.001363122,0.01614597],"study_design_scores_gemma":[0.002763589,0.00103641,0.6954708,0.002666097,0.2608145,0.00001626025,0.0001934348,0.000156971,0.0002212235,0.0001317227,0.03498246,0.00154659],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1133314,0.8853289,0.0001549261,0.0001234296,0.00003285391,0.0005534256,0.0004562665,0.00001079702,0.000008027077],"genre_scores_gemma":[0.2260689,0.7718025,0.0006001545,0.0003612195,0.0000830052,0.00005142462,0.0008121043,0.0000879492,0.000132731],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6347937,"threshold_uncertainty_score":0.9998533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1072248241697333,"score_gpt":0.3230300340983067,"score_spread":0.2158052099285734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}