{"id":"W2029891724","doi":"10.1038/sj.bjp.0704683","title":"Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (<i>db/db</i>−/−) mice: role of decreased tetrahydrobiopterin bioavailability","year":2002,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Calgary","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale","keywords":"Endocrinology; Internal medicine; Mesenteric arteries; Chemistry; Phenylephrine; Sodium nitroprusside; Acetylcholine; Superoxide dismutase; Nitric oxide synthase; SMA*; Nitric oxide; Medicine; Oxidative stress; Artery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002553877,0.000803575,0.0007196005,0.0005576276,0.0002363358,0.0004564573,0.0003854006,0.0007414282,0.001930721],"category_scores_gemma":[0.000215287,0.0004443419,0.0005564921,0.0002768312,0.0004924421,0.0003585921,0.0002828519,0.001503826,0.0005097213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002581048,"about_ca_system_score_gemma":0.0001357753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004176869,"about_ca_topic_score_gemma":0.0004717777,"domain_scores_codex":[0.9997619,0.00003975784,0.00004079408,0.00006629248,0.0000492088,0.00004209184],"domain_scores_gemma":[0.9994687,0.00002991933,0.0002075465,0.00005013962,0.00003305965,0.000210623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007001357,0.00006092477,0.0004513863,0.00004689543,0.00001596556,0.0001857163,0.00001375883,0.00002513651,0.9978823,0.00006811989,0.00002786869,0.0005217532],"study_design_scores_gemma":[0.0002488657,0.001714373,0.07068922,0.00003627714,0.000251112,0.003247546,0.0001871626,0.00135053,0.920218,0.0002401767,0.001790405,0.00002624367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947509,0.001354063,0.002123061,0.0001942065,0.00005942885,0.00002979023,0.0005512087,0.00009764897,0.0008397033],"genre_scores_gemma":[0.9932654,0.001544742,0.002401084,0.00015989,0.0000576474,0.00009983421,0.0007867748,0.00005277607,0.001631931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001930721,"threshold_uncertainty_score":0.006458879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01018833588210198,"score_gpt":0.222132406411103,"score_spread":0.211944070529001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}