{"id":"W2029891724","doi":"10.1038/sj.bjp.0704683","title":"Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (<i>db/db</i>−/−) mice: role of decreased tetrahydrobiopterin bioavailability","year":2002,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Calgary","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale","keywords":"Endocrinology; Internal medicine; Mesenteric arteries; Chemistry; Phenylephrine; Sodium nitroprusside; Acetylcholine; Superoxide dismutase; Nitric oxide synthase; SMA*; Nitric oxide; Medicine; Oxidative stress; Artery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004777091,0.0001934644,0.0008859935,0.0002983523,0.00002856805,0.00001031692,0.0001825493,0.0001528343,0.00268437],"category_scores_gemma":[0.000176925,0.0002108978,0.0002713455,0.0002388274,0.0002328054,0.00009955365,0.00003818461,0.0004007568,0.00001382378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001105036,"about_ca_system_score_gemma":0.00007534339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001013707,"about_ca_topic_score_gemma":0.0001383625,"domain_scores_codex":[0.9977703,0.0003810684,0.001062089,0.0002358336,0.0002274409,0.0003232787],"domain_scores_gemma":[0.9986154,0.0003396242,0.0005689616,0.0001141544,0.0001862585,0.0001755851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001516846,0.00124717,0.0106709,0.0001742417,0.0002057714,0.002937872,0.0002015399,0.0000145027,0.9575824,5.242296e-7,0.0004332901,0.02501497],"study_design_scores_gemma":[0.01208386,0.001504419,0.01369899,0.00044277,0.0006340402,0.005185433,0.0002349008,0.0006954249,0.963794,0.00008525129,0.001442688,0.0001982106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940408,0.004414125,0.00006775493,0.0001995907,0.0006263093,0.0003178529,0.0001304487,0.00001293594,0.0001901838],"genre_scores_gemma":[0.9973195,0.001167029,0.0008093099,0.0002111117,0.0003767376,0.000008251062,0.00001023254,0.00002760347,0.00007027249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02481676,"threshold_uncertainty_score":0.9982273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01018833588210198,"score_gpt":0.222132406411103,"score_spread":0.211944070529001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}