{"id":"W2029898167","doi":"10.1016/j.brainres.2007.12.031","title":"Upregulation of GSK3β expression in frontal and temporal cortex in ALS with cognitive impairment (ALSci)","year":2008,"lang":"de","type":"article","venue":"Brain Research","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Scottish Rite Charitable Foundation of Canada; Target ALS","keywords":"Downregulation and upregulation; Tau protein; Hyperphosphorylation; Hippocampus; Hippocampal formation; Western blot; GSK-3; Chemistry; Phosphorylation; Neuroscience; Biology; Psychology; Internal medicine; Endocrinology; Cell biology; Medicine; Alzheimer's disease; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003440346,0.0002802664,0.0006957178,0.001066444,0.000170507,0.00003345962,0.0002220713,0.0003108393,0.0004923724],"category_scores_gemma":[0.0008478539,0.0002201612,0.0000553097,0.001255552,0.001450203,0.0002799023,0.0004308528,0.001242706,0.00006190243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005051888,"about_ca_system_score_gemma":0.0008426036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003766479,"about_ca_topic_score_gemma":0.0006280917,"domain_scores_codex":[0.9932369,0.001628297,0.0007509675,0.0007857116,0.002458276,0.001139876],"domain_scores_gemma":[0.9973034,0.001287408,0.0001330131,0.0003833511,0.000480709,0.0004121638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00882131,0.001401864,0.9026928,0.0004397233,0.00008428691,0.001222931,0.007637721,0.00001655176,0.0716657,0.00002560869,0.00207064,0.0039209],"study_design_scores_gemma":[0.009753995,0.002954012,0.973265,0.004098285,0.00001083033,0.00002589532,0.001727732,0.001923099,0.005810433,0.0001142962,0.0001073611,0.0002090538],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903674,0.004288271,0.00002665638,0.002055589,0.00004366759,0.002720549,0.00003854241,0.00001240102,0.0004469805],"genre_scores_gemma":[0.996552,0.001434121,0.0002599313,0.00004898934,0.0001688802,0.000150967,0.0001019961,0.00005061216,0.00123252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07057224,"threshold_uncertainty_score":0.8977912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07601135590524147,"score_gpt":0.3764481843306,"score_spread":0.3004368284253586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}