{"id":"W2029909776","doi":"10.1159/000345604","title":"Cumulative Meta-Analysis for Genetic Association: When Is a New Study Worthwhile?","year":2012,"lang":"en","type":"article","venue":"Human Heredity","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; York University; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"Meta-analysis; Single-nucleotide polymorphism; SNP; Genetic association; Genetics; Context (archaeology); Genome-wide association study; Trait; Biology; Sample size determination; Genotype; Statistics; Medicine; Gene; Mathematics; Computer science; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009548464,0.0002039106,0.0006319571,0.00006279373,0.0002223154,0.00002336032,0.0001839987,0.0002240925,0.001005776],"category_scores_gemma":[0.0002701567,0.0001838993,0.0008571673,0.000145312,0.00001979092,0.000005809139,0.00009002659,0.00008832126,0.00002520805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006034804,"about_ca_system_score_gemma":0.00004829535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002784106,"about_ca_topic_score_gemma":0.0007952098,"domain_scores_codex":[0.9982662,0.0002724096,0.0004242914,0.000405893,0.0001899837,0.0004412537],"domain_scores_gemma":[0.9987234,0.00009176457,0.0003535686,0.0004751993,0.0001851162,0.0001709547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00001068411,0.0002781623,0.860619,0.000003234604,0.05524486,1.800951e-7,0.001057688,0.0001428474,0.0002093116,0.00002713561,0.08227362,0.0001332473],"study_design_scores_gemma":[0.0006915564,0.0003337785,0.8929478,2.614664e-7,0.05210411,6.342384e-7,0.0002618702,0.00004365851,0.0002085801,0.001524438,0.05157137,0.0003119703],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866036,0.001716293,0.009368205,0.0005935405,0.0002133571,0.0007868629,0.0001358196,0.00001976455,0.0005625631],"genre_scores_gemma":[0.9786838,0.000008982171,0.004557907,0.0005539321,0.001246545,0.0001653553,0.0001792247,0.00002011591,0.01458414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03232874,"threshold_uncertainty_score":0.9999074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.148371273515872,"score_gpt":0.3618152803059576,"score_spread":0.2134440067900857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}