{"id":"W2029917664","doi":"10.1210/en.2009-0838","title":"Central Insulin Signaling Is Attenuated by Long-Term Insulin Exposure via Insulin Receptor Substrate-1 Serine Phosphorylation, Proteasomal Degradation, and Lysosomal Insulin Receptor Degradation","year":2009,"lang":"en","type":"article","venue":"Endocrinology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Insulin receptor; Insulin receptor substrate; Insulin; Internal medicine; IRS1; Endocrinology; Insulin resistance; P70-S6 Kinase 1; IRS2; Biology; Protein kinase B; Phosphorylation; Hyperinsulinemia; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001556429,0.000473464,0.0004887216,0.0001830686,0.0001445789,0.0003248308,0.0002277087,0.0001925414,0.001130512],"category_scores_gemma":[0.0001328843,0.0001508819,0.0003573125,0.0001776243,0.0002590659,0.0003262236,0.0002513399,0.0008943967,0.0002300601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002379427,"about_ca_system_score_gemma":0.0001604223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003592007,"about_ca_topic_score_gemma":0.0006194424,"domain_scores_codex":[0.9998201,0.000022626,0.00002557403,0.00003326885,0.00004025128,0.00005821395],"domain_scores_gemma":[0.9998765,0.00001386938,0.00003887836,0.00002167953,0.00001301456,0.00003611187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003644408,0.00003489844,0.0001394707,0.00002986936,0.00000602278,0.000040961,0.000008949534,0.00001642742,0.9984438,0.0000299247,0.00002387938,0.0008613136],"study_design_scores_gemma":[0.00002400379,0.0006027881,0.01039575,0.000008774358,0.00001779793,0.0002244558,0.00003535568,0.0003477487,0.9873114,0.0000443831,0.0009829631,0.000004581422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950662,0.002570962,0.001251661,0.00009050136,0.00003853636,0.00001237741,0.0002551507,0.00006076582,0.0006538466],"genre_scores_gemma":[0.9946301,0.001725008,0.001628331,0.00004800972,0.00002187239,0.00004996837,0.0005255809,0.00001941308,0.001351631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001130512,"threshold_uncertainty_score":0.003781974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01311782655275423,"score_gpt":0.2400765804725977,"score_spread":0.2269587539198434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}