{"id":"W2029917664","doi":"10.1210/en.2009-0838","title":"Central Insulin Signaling Is Attenuated by Long-Term Insulin Exposure via Insulin Receptor Substrate-1 Serine Phosphorylation, Proteasomal Degradation, and Lysosomal Insulin Receptor Degradation","year":2009,"lang":"en","type":"article","venue":"Endocrinology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Insulin receptor; Insulin receptor substrate; Insulin; Internal medicine; IRS1; Endocrinology; Insulin resistance; P70-S6 Kinase 1; IRS2; Biology; Protein kinase B; Phosphorylation; Hyperinsulinemia; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002079685,0.0006241202,0.0008527649,0.0003361155,0.0003068004,0.00008341388,0.0002040774,0.0004223724,0.001655114],"category_scores_gemma":[0.0004671919,0.0006085417,0.0001398682,0.0007245618,0.0002253077,0.0004413035,0.000058328,0.0006693937,0.000230672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002347286,"about_ca_system_score_gemma":0.0002441554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001119055,"about_ca_topic_score_gemma":0.00001386012,"domain_scores_codex":[0.9960634,0.0002613729,0.001161694,0.0009871521,0.0004789329,0.001047411],"domain_scores_gemma":[0.9979411,0.0001505848,0.000454451,0.0005074958,0.0004557456,0.0004906558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003140123,0.001307249,0.4962412,0.0001835422,0.0003813404,0.00007355237,0.0008489727,0.00002931164,0.3978629,0.0003140169,0.00559734,0.09402052],"study_design_scores_gemma":[0.01090453,0.002171824,0.542141,0.0001825511,0.0002149853,0.0002083167,0.0001805757,0.0005643663,0.4373562,0.0001657172,0.005128276,0.0007817338],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864132,0.005398928,0.001164207,0.00439256,0.0004928923,0.00138712,0.000120486,0.000402626,0.0002279687],"genre_scores_gemma":[0.9893539,0.001477105,0.003147736,0.001554653,0.000434741,0.0001144885,0.002556486,0.00006676598,0.001294143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09323879,"threshold_uncertainty_score":0.9996366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01311782655275423,"score_gpt":0.2400765804725977,"score_spread":0.2269587539198434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}