{"id":"W2029918034","doi":"10.4161/epi.3.5.6868","title":"Hypermethylation of the ABCB1 downstream gene promoter accompanies ABCB1 gene amplification and increased expression in docetaxel-resistant MCF-7 breast tumor cells","year":2008,"lang":"en","type":"article","venue":"Epigenetics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Laurentian University","funders":"McMaster University; Sanofi","keywords":"Docetaxel; Biology; DNA methylation; Cancer research; Gene expression; Epigenetics; Promoter; Gene; Drug resistance; MCF-7; Molecular biology; Genetics; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000203722,0.0002087753,0.0003578629,0.0001213656,0.0001228227,0.00001019557,0.0001376471,0.000107765,0.00004025393],"category_scores_gemma":[0.00001694383,0.0001436664,0.00008780207,0.0002623961,0.0001806558,0.00004983629,0.0000346978,0.0001572501,0.000004737136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005911473,"about_ca_system_score_gemma":0.00009887908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001093603,"about_ca_topic_score_gemma":0.00007433584,"domain_scores_codex":[0.9984638,0.00007456735,0.0005075737,0.0003234642,0.0003854454,0.0002451542],"domain_scores_gemma":[0.9990419,0.00003706858,0.000213991,0.0004762205,0.0001216688,0.0001091248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002252485,0.0002358318,0.06606932,0.0001043227,0.00001471393,0.00002037558,0.0004817896,0.00003960666,0.9323332,0.00001644658,0.00001286114,0.0004462986],"study_design_scores_gemma":[0.0006897547,0.00004583125,0.4661635,0.0001035677,0.00003861657,0.00003465425,0.00006425653,0.00006722788,0.5325121,0.00007720435,0.0001139162,0.0000893205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975845,0.0007277736,0.0005339179,0.0001439899,0.000111068,0.0006534968,0.00008941974,0.00002405089,0.000131808],"genre_scores_gemma":[0.9919698,0.0003929138,0.007208568,0.00004667018,0.00008451814,0.00002309754,0.00006031764,0.00002810039,0.0001859846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4000942,"threshold_uncertainty_score":0.5858545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01297205757442453,"score_gpt":0.2157305313708048,"score_spread":0.2027584737963803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}