{"id":"W2029955024","doi":"10.1016/s0092-8674(02)00659-1","title":"A Ca2+ Switch Aligns the Active Site of Calpain","year":2002,"lang":"en","type":"article","venue":"Cell","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":327,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Calpain; Calpastatin; Proteolysis; Biology; Gene isoform; Neurodegeneration; Cell biology; Protease; Proteases; Cytoskeleton; Endogeny; Biochemistry; Enzyme; Internal medicine; Disease; Gene; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002531991,0.0003738006,0.0004305663,0.0002708131,0.0003914808,0.0007950709,0.0008569183,0.0006564426,0.003154539],"category_scores_gemma":[0.0005159606,0.0002689758,0.000193736,0.0002922715,0.0005283009,0.0006845845,0.0003894752,0.0008914151,0.0007470701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005768195,"about_ca_system_score_gemma":0.0003552926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004902374,"about_ca_topic_score_gemma":0.0009700648,"domain_scores_codex":[0.9998549,0.000009697205,0.0000116602,0.00005778967,0.00003330226,0.00003259497],"domain_scores_gemma":[0.9997492,0.00005552271,0.00005407548,0.00004411476,0.0000253151,0.00007168691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002013235,0.00002263282,0.0001021789,0.00002840788,0.000005152946,0.0001071109,0.00001372738,0.00007808254,0.9955711,0.001285387,0.0002277737,0.002357214],"study_design_scores_gemma":[0.0001724406,0.0001806059,0.002024387,0.000005455539,0.00001546114,0.0005257213,0.0000433272,0.001818291,0.9873418,0.001178963,0.006676869,0.00001680293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9512131,0.002698269,0.03094228,0.00204409,0.001514548,0.0001420078,0.0004967372,0.001205977,0.00974293],"genre_scores_gemma":[0.9884279,0.0007040546,0.007259983,0.0005728775,0.0001686473,0.00004086323,0.0002005913,0.0001079991,0.002517092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003154539,"threshold_uncertainty_score":0.010553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00891581939636306,"score_gpt":0.2011768959304251,"score_spread":0.192261076534062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}