{"id":"W2029983315","doi":"10.1021/nn2013707","title":"Traceable Multifunctional Micellar Nanocarriers for Cancer-Targeted Co-delivery of MDR-1 siRNA and Doxorubicin","year":2011,"lang":"en","type":"article","venue":"ACS Nano","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":408,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Nanocarriers; In vivo; Doxorubicin; Drug delivery; Chemistry; Intracellular; Biophysics; In vitro; Multiple drug resistance; Pharmacology; Biochemistry; Biology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009432995,0.0001290142,0.0001502541,0.00004153149,0.00006495935,0.000006629937,0.0001231782,0.0001434647,0.00006456574],"category_scores_gemma":[0.00002330541,0.0001220309,0.00007530594,0.00004409783,0.00009258194,0.000006801816,0.00003421161,0.00003986215,0.000003892411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008879405,"about_ca_system_score_gemma":0.00008527679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002506927,"about_ca_topic_score_gemma":0.00007735498,"domain_scores_codex":[0.9992564,0.00001901487,0.0001895637,0.0002683353,0.00007399166,0.0001927053],"domain_scores_gemma":[0.9995105,0.00001366669,0.00009069953,0.0001764364,0.0001474962,0.0000611955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003802877,0.00004389514,0.004064324,0.00002939563,0.0001012393,7.773434e-7,0.0001453125,0.000009852479,0.9884952,0.00001741356,0.004640723,0.002071575],"study_design_scores_gemma":[0.0006597728,0.0004517852,0.001536642,0.00001660897,0.00003789383,0.000003983222,0.0001841909,0.00003815074,0.9797489,0.00004467449,0.01712822,0.0001491669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957282,0.002942154,0.0002062537,0.00002153373,0.0002005075,0.0001838255,0.000147299,0.000006740089,0.0005634726],"genre_scores_gemma":[0.9966415,0.0008418045,0.0007303004,0.0001876327,0.00009177335,0.00003599537,0.00009864652,0.0000165123,0.001355855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01248749,"threshold_uncertainty_score":0.4976275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0236850625566875,"score_gpt":0.2513000202645856,"score_spread":0.2276149577078981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}