{"id":"W2029983315","doi":"10.1021/nn2013707","title":"Traceable Multifunctional Micellar Nanocarriers for Cancer-Targeted Co-delivery of MDR-1 siRNA and Doxorubicin","year":2011,"lang":"en","type":"article","venue":"ACS Nano","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":408,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Nanocarriers; In vivo; Doxorubicin; Drug delivery; Chemistry; Intracellular; Biophysics; In vitro; Multiple drug resistance; Pharmacology; Biochemistry; Biology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003105039,0.0004141199,0.0002910238,0.0002217339,0.0001448113,0.0003907972,0.0002766401,0.0004742513,0.00072684],"category_scores_gemma":[0.0002609984,0.0001832388,0.0002438619,0.000101756,0.0002241179,0.0005012854,0.0002571584,0.0005224939,0.0004979287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005287033,"about_ca_system_score_gemma":0.0002397454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003587019,"about_ca_topic_score_gemma":0.0006596159,"domain_scores_codex":[0.999799,0.00003149711,0.00001815956,0.00005477191,0.00006605884,0.00003065682],"domain_scores_gemma":[0.9998872,0.00002453551,0.00003677895,0.00001341128,0.00002254874,0.00001546359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002918053,0.00001359152,0.00002826079,0.00003266023,0.000004267991,0.00003238219,0.00001664457,0.0001752011,0.996454,0.0002600728,0.00004551429,0.002908249],"study_design_scores_gemma":[0.000009697101,0.0001013925,0.000102484,0.000002534424,0.000010152,0.00009848535,0.000003558047,0.001140452,0.9956858,0.00003095012,0.002809415,0.000005001603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7892219,0.01359181,0.1905676,0.0007464424,0.0002185011,0.0003747005,0.0002928187,0.001174396,0.003811808],"genre_scores_gemma":[0.9240873,0.003960432,0.06551491,0.0002092899,0.00005527921,0.0001826924,0.0002382385,0.0001059152,0.00564588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00072684,"threshold_uncertainty_score":0.003836036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0236850625566875,"score_gpt":0.2513000202645856,"score_spread":0.2276149577078981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}