{"id":"W2029988735","doi":"10.1006/jmbi.2000.3717","title":"Binding of the epstein-barr virus major envelope glycoprotein gp350 results in the upregulation of the TNF-α gene expression in monocytic cells via NF-κb involving PKC, PI3-K and tyrosine kinases","year":2000,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Viral-associated cancers and disorders","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Medical Research Council","keywords":"Biology; Tumor necrosis factor alpha; Molecular biology; Cytokine; Interleukin 19; Tyrosine kinase; Monocyte; Signal transduction; Fc receptor; Epstein–Barr virus; Cell biology; Cancer research; Antibody; Virus; Virology; Interleukin; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000168026,0.000459221,0.00028864,0.0002677546,0.0002178178,0.0002805986,0.0001181459,0.000280828,0.001672233],"category_scores_gemma":[0.0001379794,0.0002190697,0.0004999123,0.0002630823,0.0002454771,0.0002194264,0.0002264601,0.0006173195,0.0006823331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004705079,"about_ca_system_score_gemma":0.0002162189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007466417,"about_ca_topic_score_gemma":0.0008727188,"domain_scores_codex":[0.9997656,0.00003479576,0.00001642422,0.00002894375,0.00005015968,0.0001040925],"domain_scores_gemma":[0.9998946,0.00002039391,0.000020018,0.0000177752,0.000008917309,0.00003821816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003962243,0.00004282451,0.0001613932,0.00003206515,0.000005576308,0.00008124914,0.00001817582,0.00002904942,0.9984995,0.00008963371,0.00004011398,0.0006041065],"study_design_scores_gemma":[0.00004774138,0.0006424341,0.01165727,0.000009405086,0.00002020921,0.0005420784,0.00006673388,0.0004943411,0.9843151,0.000146323,0.002051916,0.000006427243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948967,0.00236093,0.001380858,0.00008417254,0.00006579477,0.00002025608,0.0003189187,0.00005602963,0.0008163801],"genre_scores_gemma":[0.9946789,0.00121463,0.001302278,0.00005924274,0.00001847457,0.00002306357,0.0009100127,0.000009850249,0.001783568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001672233,"threshold_uncertainty_score":0.005594194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01029185158025786,"score_gpt":0.2506616709279092,"score_spread":0.2403698193476513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}