{"id":"W2030000363","doi":"10.1371/journal.pone.0076370","title":"SOCS-1 Mediates Ubiquitylation and Degradation of GM-CSF Receptor","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Cancer Research Society","keywords":"Ubiquitin ligase; SOCS2; Ubiquitin; SOCS3; Signal transduction; Cell biology; Cytokine; Cytokine receptor; Downregulation and upregulation; Biology; Tyrosine kinase; Granulocyte macrophage colony-stimulating factor; Granulocyte colony-stimulating factor receptor; Macrophage colony-stimulating factor; Haematopoiesis; Cancer research; Immunology; Macrophage; STAT3; Biochemistry; Suppressor; Stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00005738651,0.00005256561,0.0001410252,0.00006505372,0.00002866494,0.00001040075,0.00001780896,0.00003879471,0.001207295],"category_scores_gemma":[0.000181815,0.00004543303,0.00002218554,0.00006792513,0.00002638635,0.0001414904,0.00001209703,0.00007191819,0.00007910845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001801775,"about_ca_system_score_gemma":0.00001842368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001198577,"about_ca_topic_score_gemma":0.000006530295,"domain_scores_codex":[0.9995157,0.00001270155,0.0001602971,0.00009086939,0.0001514145,0.00006907726],"domain_scores_gemma":[0.9995296,0.00006139604,0.0000713198,0.00009013674,0.0001958898,0.0000516347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001588707,0.0003682626,0.01145608,0.00008957769,0.00006594939,1.055992e-7,0.0001494872,2.457431e-7,0.9844192,0.00009457185,0.0007591632,0.002581508],"study_design_scores_gemma":[0.0004220856,0.0002680055,0.03105562,0.0002612519,0.0001212852,0.00000150979,0.00009276676,0.001085132,0.9662434,0.0002201469,0.0001701149,0.00005863555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968412,0.0001007629,0.00006352474,0.001489801,0.00003028871,0.0002363912,0.000007483533,0.00003096029,0.001199577],"genre_scores_gemma":[0.9955499,0.0001019429,0.003288521,0.00009310614,0.0001201458,0.00002367055,0.00007376628,0.000008907507,0.0007400595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01959954,"threshold_uncertainty_score":0.9997057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05480640268512552,"score_gpt":0.2499388811336172,"score_spread":0.1951324784484917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}