{"id":"W2030000363","doi":"10.1371/journal.pone.0076370","title":"SOCS-1 Mediates Ubiquitylation and Degradation of GM-CSF Receptor","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Cancer Research Society","keywords":"Ubiquitin ligase; SOCS2; Ubiquitin; SOCS3; Signal transduction; Cell biology; Cytokine; Cytokine receptor; Downregulation and upregulation; Biology; Tyrosine kinase; Granulocyte macrophage colony-stimulating factor; Granulocyte colony-stimulating factor receptor; Macrophage colony-stimulating factor; Haematopoiesis; Cancer research; Immunology; Macrophage; STAT3; Biochemistry; Suppressor; Stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002083466,0.0004502778,0.000208037,0.000271211,0.0003004628,0.0004032007,0.0001437932,0.0002102867,0.002187528],"category_scores_gemma":[0.0001557538,0.0001147045,0.0003673741,0.0001107207,0.0002584254,0.0002391465,0.0003216183,0.0003666297,0.0006198936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004607739,"about_ca_system_score_gemma":0.0003250799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003455018,"about_ca_topic_score_gemma":0.0007163737,"domain_scores_codex":[0.9998406,0.00002717932,0.00001159868,0.00002669379,0.00002822749,0.00006565223],"domain_scores_gemma":[0.9998816,0.000008736317,0.00004793139,0.0000103706,0.0000124139,0.00003890504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003775451,0.00003159088,0.0009975445,0.0001710532,0.0000135414,0.0001819751,0.00003510528,0.0001959413,0.9927729,0.0007301648,0.0003951301,0.004097608],"study_design_scores_gemma":[0.00006996645,0.0005062763,0.02217473,0.0000298109,0.00002705054,0.001591662,0.00008709233,0.003307415,0.9601361,0.0003825419,0.01167249,0.00001491909],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852953,0.007851193,0.00225584,0.0003230794,0.0001036328,0.00003253189,0.0006264347,0.0001318085,0.003380316],"genre_scores_gemma":[0.9963617,0.001262964,0.0004005003,0.00004254967,0.00001869881,0.00001185548,0.0004428492,0.000005576625,0.00145343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002187528,"threshold_uncertainty_score":0.00731796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05480640268512552,"score_gpt":0.2499388811336172,"score_spread":0.1951324784484917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}