{"id":"W2030004944","doi":"10.1016/j.bbagrm.2014.12.005","title":"Why should cancer biologists care about tRNAs? tRNA synthesis, mRNA translation and the control of growth","year":2014,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Canadian HIV Trials Network, Canadian Institutes of Health Research","keywords":"Transfer RNA; Translation (biology); Protein biosynthesis; Biology; Translational regulation; Carcinogenesis; Messenger RNA; RNA polymerase III; Cell biology; RNA; Biochemistry; Cancer; Genetics; RNA polymerase; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005507221,0.0008350711,0.001827673,0.0001504414,0.0002483873,0.00007337602,0.0008185317,0.0008682921,0.00001397302],"category_scores_gemma":[0.00005911059,0.0005696188,0.0009917325,0.0002473448,0.000626434,0.00001299277,0.0001207707,0.0003111106,0.000002893979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006950091,"about_ca_system_score_gemma":0.000383523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008854018,"about_ca_topic_score_gemma":0.00002422882,"domain_scores_codex":[0.9963344,0.0008063529,0.0009499598,0.001094804,0.0003656388,0.0004488869],"domain_scores_gemma":[0.9971253,0.0001506374,0.001085063,0.001249638,0.0002360749,0.0001532847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002637512,0.00008691855,7.879144e-8,0.003447521,0.001058187,8.281837e-7,0.0001274297,0.000005600576,0.698011,0.002397995,0.0004568142,0.2941439],"study_design_scores_gemma":[0.00154404,0.0002350535,0.00002577168,0.001859016,0.002551894,0.00001780727,0.00004650402,0.000069694,0.8952197,0.0002737458,0.09714794,0.001008863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0104107,0.9824258,0.003658355,0.0004652892,0.0003420555,0.001610906,0.0009678009,0.00003735121,0.0000817145],"genre_scores_gemma":[0.2591108,0.738618,0.00029207,0.0003379882,0.0003978331,0.0007416322,0.0003514194,0.0001120491,0.00003818978],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.293135,"threshold_uncertainty_score":0.9996755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02979646953612798,"score_gpt":0.2932733524324137,"score_spread":0.2634768828962857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}