{"id":"W2030022026","doi":"10.1091/mbc.e11-02-0135","title":"Munc18-1 domain-1 controls vesicle docking and secretion by interacting with syntaxin-1 and chaperoning it to the plasma membrane","year":2011,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Syntaxin; Cell biology; Munc-18; Biology; Exocytosis; Secretion; Syntaxin 3; Docking (animal); Vesicle fusion; Chaperone (clinical); Mutant; SNARE complex; STX1A; Vesicle; Biochemistry; Synaptic vesicle; Membrane; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002868181,0.000146987,0.0001488897,0.00002306042,0.0001272844,0.00001320556,0.0001770868,0.0001142378,0.000009983021],"category_scores_gemma":[0.00003064147,0.00009086969,0.00005026778,0.00005476838,0.0001875895,0.000004802584,0.000103897,0.0001081012,9.292945e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005347864,"about_ca_system_score_gemma":0.00001383861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006545866,"about_ca_topic_score_gemma":0.00006166109,"domain_scores_codex":[0.999159,0.0001310255,0.0001673935,0.00028519,0.00006373924,0.0001936913],"domain_scores_gemma":[0.9995118,0.00002852464,0.0001156868,0.0002572796,0.00003543104,0.00005126323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002509335,0.00001851517,0.002146605,0.00001555686,0.00004454739,0.000001841871,0.0007007384,0.00002026637,0.9964203,0.00008441951,0.000008679628,0.0002876119],"study_design_scores_gemma":[0.0006133768,0.0003719518,0.0005806391,0.00003605539,0.00004722291,0.00003823088,0.000531038,0.0001036627,0.9925184,0.00004748175,0.004971374,0.0001405978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821364,0.0007437819,0.01557966,0.0004570566,0.00007425685,0.0002706859,0.000009067428,0.000005274054,0.0007238601],"genre_scores_gemma":[0.9987329,0.00005861529,0.000648689,0.0003600809,0.00002316952,0.00001333137,0.00008680044,0.00001673542,0.00005973834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01659648,"threshold_uncertainty_score":0.3705558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005958474823533193,"score_gpt":0.196764386768208,"score_spread":0.1908059119446747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}