{"id":"W2030098953","doi":"10.1007/s00280-006-0225-6","title":"Effect of histone deacetylase inhibitor LAQ824 on antineoplastic action of 5-Aza-2′-deoxycytidine (decitabine) on human breast carcinoma cells","year":2006,"lang":"en","type":"article","venue":"Cancer Chemotherapy and Pharmacology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Decitabine; Deoxycytidine; Histone deacetylase inhibitor; Chemistry; Cancer research; Histone deacetylase; Pharmacology; Azacitidine; Histone; Medicine; Internal medicine; Chemotherapy; DNA methylation; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001529329,0.0001841101,0.000260236,0.00007443597,0.0000530566,0.000003357103,0.00006910222,0.0001524031,0.0000801705],"category_scores_gemma":[0.000003865701,0.0001662906,0.00007542291,0.00007632942,0.0001187776,0.000002957307,0.00001631615,0.00009178319,9.864626e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002794451,"about_ca_system_score_gemma":0.0000325103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008999916,"about_ca_topic_score_gemma":0.00001429498,"domain_scores_codex":[0.9991007,0.0001075661,0.0002464474,0.0002854722,0.00009315275,0.000166653],"domain_scores_gemma":[0.9995076,0.00006201427,0.0001898171,0.0001290171,0.00006270982,0.0000488083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001545064,0.0003150155,0.001956545,0.0001446658,0.00004495601,0.000001239833,0.0000196771,0.0002690356,0.9902102,0.00001449731,0.0009512274,0.004527867],"study_design_scores_gemma":[0.005505969,0.00234967,0.004147882,0.00002117587,0.00004942499,0.000002230372,0.000002417035,0.00006524437,0.9856571,0.00001391401,0.002046229,0.0001387412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997538,0.001353168,0.00006424941,0.00009263811,0.0003993198,0.0002360392,0.00006509123,0.000006527137,0.0002449154],"genre_scores_gemma":[0.9983631,0.0005989206,0.00001901853,0.0001062788,0.0006005227,0.00002499639,0.00005215238,0.00002562556,0.0002094243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004553108,"threshold_uncertainty_score":0.6781136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01136557177753556,"score_gpt":0.3456122280967449,"score_spread":0.3342466563192094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}