{"id":"W2030139904","doi":"10.1055/s-2009-1216529","title":"Preformulation Evaluation of Δ9-Tetrahydrocannabinol Prodrugs – a Tool for Establishing Physicochemical Characteristics of Compounds at an Early Stage","year":2009,"lang":"en","type":"article","venue":"Planta Medica","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Drug Abuse; Agricultural Research Service; University of British Columbia; University of Illinois at Urbana-Champaign; Chinese Academy of Sciences; Kurukshetra University; University of Illinois at Chicago; National Oceanic and Atmospheric Administration; U.S. Food and Drug Administration; National Science Foundation of Sri Lanka; University of Colombo; U.S. Department of Agriculture; Western Carolina University; International Science Council; National Center for Complementary and Alternative Medicine; China Academy of Traditional Chinese Medicine; National Institutes of Health; National Center for Research Resources; National Institute of Allergy and Infectious Diseases; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; Hong Kong Polytechnic University; National Science Foundation; Deutsche Krebshilfe; National Natural Science Foundation of China; Tata Trusts; University Grants Commission; Wake Forest University","keywords":"Chemistry; Pharmacology; Permeation; Dronabinol; Pharmacokinetics; Prodrug; Bioavailability; Capsule; Active ingredient; Chromatography; Cannabinoid; Medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000629075,0.0002734832,0.0001779844,0.0002334689,0.0001119197,0.0002198137,0.0002037067,0.0002912065,0.001353721],"category_scores_gemma":[0.0005814282,0.000136656,0.0002084631,0.0001375683,0.0002042362,0.000199597,0.0000948219,0.0004597209,0.0002564058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000162715,"about_ca_system_score_gemma":0.0001714365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005439633,"about_ca_topic_score_gemma":0.001114643,"domain_scores_codex":[0.9998172,0.00006021218,0.00001253048,0.00003399422,0.00004955187,0.00002648145],"domain_scores_gemma":[0.9997851,0.00007330471,0.00004930097,0.00002616291,0.00003826083,0.00002781592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007164178,0.0003288756,0.0001258251,0.00007972722,0.00001234948,0.00003278671,0.00004213583,0.000236171,0.9889887,0.00008919706,0.00006492876,0.009282823],"study_design_scores_gemma":[0.0003095428,0.03174486,0.003639443,0.00001589026,0.00006405303,0.0001611313,0.00003887745,0.001188072,0.9596117,0.00008580804,0.003126122,0.00001444397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988279,0.00143431,0.008021299,0.00007200936,0.00004739553,0.0007044035,0.0003042534,0.00006467861,0.001072641],"genre_scores_gemma":[0.9831715,0.001100672,0.01251133,0.00006575097,0.00001931269,0.0002486281,0.0003381347,0.00002315802,0.002521462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001353721,"threshold_uncertainty_score":0.004528642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03291390968689942,"score_gpt":0.3308190461751088,"score_spread":0.2979051364882094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}