{"id":"W2030139904","doi":"10.1055/s-2009-1216529","title":"Preformulation Evaluation of Δ9-Tetrahydrocannabinol Prodrugs – a Tool for Establishing Physicochemical Characteristics of Compounds at an Early Stage","year":2009,"lang":"en","type":"article","venue":"Planta Medica","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Drug Abuse; Agricultural Research Service; University of British Columbia; University of Illinois at Urbana-Champaign; Chinese Academy of Sciences; Kurukshetra University; University of Illinois at Chicago; National Oceanic and Atmospheric Administration; U.S. Food and Drug Administration; National Science Foundation of Sri Lanka; University of Colombo; U.S. Department of Agriculture; Western Carolina University; International Science Council; National Center for Complementary and Alternative Medicine; China Academy of Traditional Chinese Medicine; National Institutes of Health; National Center for Research Resources; National Institute of Allergy and Infectious Diseases; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; Hong Kong Polytechnic University; National Science Foundation; Deutsche Krebshilfe; National Natural Science Foundation of China; Tata Trusts; University Grants Commission; Wake Forest University","keywords":"Chemistry; Pharmacology; Permeation; Dronabinol; Pharmacokinetics; Prodrug; Bioavailability; Capsule; Active ingredient; Chromatography; Cannabinoid; Medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001170204,0.0001481196,0.0004278844,0.000145523,0.00005882886,0.00001719368,0.0001491243,0.0001315405,0.00007231021],"category_scores_gemma":[0.0006008612,0.0001252802,0.00009990643,0.0001874203,0.00009910206,0.0002173598,0.00003070408,0.0001829234,0.000001249343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002112719,"about_ca_system_score_gemma":0.0004231043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007878339,"about_ca_topic_score_gemma":0.000008864089,"domain_scores_codex":[0.9973451,0.00006174311,0.0005213096,0.0002855391,0.001484504,0.0003018396],"domain_scores_gemma":[0.9985202,0.00003389877,0.0002672391,0.0003520348,0.0006482188,0.0001784283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002809823,0.001232526,0.01442393,0.001105385,0.000103375,0.000006143838,0.002981707,0.00001056823,0.8811088,0.0002564567,0.009941393,0.08601996],"study_design_scores_gemma":[0.006081297,0.002670499,0.680396,0.0004920955,0.0004483795,0.00003159062,0.0002005967,0.02951198,0.2763467,0.0002047712,0.003314976,0.000301106],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967033,0.0000582865,0.000102617,0.001016545,0.00007732596,0.001288553,0.0002391363,0.00002744398,0.0004868545],"genre_scores_gemma":[0.9974523,0.00001911878,0.000178427,0.00007714117,0.0002419481,0.00007244309,0.001054751,0.00001789297,0.0008860207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6659721,"threshold_uncertainty_score":0.5108777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03291390968689942,"score_gpt":0.3308190461751088,"score_spread":0.2979051364882094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}