{"id":"W2030179218","doi":"10.1021/ol1030074","title":"Gram Scale Synthesis of the C(18)−C(34) Fragment of Amphidinolide C","year":2011,"lang":"en","type":"article","venue":"Organic Letters","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Chemistry; Yield (engineering); Stereochemistry; Total synthesis; Fragment (logic); Ring (chemistry); Methylation; Combinatorial chemistry; Organic chemistry; DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002898045,0.000228917,0.0003738762,0.00002835262,0.00005330374,0.000006532747,0.0008756929,0.0001454982,0.01209293],"category_scores_gemma":[0.0004476978,0.0001764983,0.0002158568,0.0002346748,0.0003255979,0.00004031416,0.0002384208,0.0002064385,0.00002203959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001504742,"about_ca_system_score_gemma":0.00006806928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000103964,"about_ca_topic_score_gemma":0.000004548454,"domain_scores_codex":[0.9984162,0.00006480686,0.0005028466,0.0003222532,0.0003871448,0.0003067753],"domain_scores_gemma":[0.9979978,0.0002765983,0.0003677526,0.001234499,0.00004538753,0.00007792323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000155178,0.0001197831,0.004466905,0.0001674818,0.0000833905,0.000002327414,0.0005972977,2.266842e-7,0.9921625,0.00001608739,0.0008301086,0.001538357],"study_design_scores_gemma":[0.0002214374,0.000005004686,0.001423053,0.0001342585,0.0001289297,0.00002415967,0.0003673434,0.000003813376,0.9971561,0.00008725073,0.000270364,0.0001782902],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878469,0.00004236232,0.0002388959,0.0007876933,0.0001699978,0.00006989016,0.00002264505,0.00005401408,0.01076764],"genre_scores_gemma":[0.996097,0.00001245725,0.003372653,0.0001990083,0.0000864509,0.00001162548,9.459806e-7,0.00005656893,0.0001632791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01207089,"threshold_uncertainty_score":0.9888102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0215923941143782,"score_gpt":0.2299385848912363,"score_spread":0.2083461907768581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}