{"id":"W2030201018","doi":"10.1097/fbp.0000000000000027","title":"In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569","year":2014,"lang":"en","type":"article","venue":"Behavioural Pharmacology","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute on Drug Abuse","keywords":"Rimonabant; Cannabinoid receptor; Inverse agonist; Pharmacology; Allosteric modulator; Cannabinoid; Agonist; Allosteric regulation; Anandamide; Receptor; Antagonist; Chemistry; Neuroscience; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002926758,0.0006016613,0.0005241702,0.0003113238,0.0001773473,0.0003540804,0.0004114647,0.000351456,0.003054725],"category_scores_gemma":[0.000168578,0.000227123,0.0003699889,0.0002146091,0.0002610123,0.0002695953,0.0001028264,0.001206418,0.0005945873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002570829,"about_ca_system_score_gemma":0.0004279781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008896501,"about_ca_topic_score_gemma":0.002065004,"domain_scores_codex":[0.9998873,0.0000247354,0.000009051401,0.00001680132,0.0000207242,0.00004130675],"domain_scores_gemma":[0.9999074,0.00002010517,0.000016208,0.000008742326,0.00001085571,0.00003673601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004682885,0.004309605,0.0001717794,0.0002424472,0.00006362587,0.0001444844,0.00004742454,0.000636381,0.9787192,0.0003320803,0.0005830523,0.01006716],"study_design_scores_gemma":[0.002364702,0.0613592,0.005609727,0.00003645008,0.0002879456,0.0005077351,0.000146696,0.003022805,0.9200259,0.0001827424,0.006422417,0.00003373436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897301,0.001704987,0.002344556,0.0002343568,0.0001086283,0.0002926988,0.0009173549,0.0001769326,0.004490324],"genre_scores_gemma":[0.9876275,0.003037388,0.002331989,0.0001916522,0.00005073369,0.0002180728,0.001435853,0.00003157887,0.005075189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003054725,"threshold_uncertainty_score":0.0102191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06956258979996491,"score_gpt":0.3926885080537214,"score_spread":0.3231259182537565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}