{"id":"W2030203690","doi":"10.2165/00139709-200625040-00004","title":"Development of the Bisquaternary Oxime HI-6 Toward Clinical Use in the Treatment of Organophosphate Nerve Agent Poisoning","year":2006,"lang":"en","type":"review","venue":"Toxicological Reviews","topic":"Pesticide Exposure and Toxicity","field":"Agricultural and Biological Sciences","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"Medicine Hat College; Response Biomedical (Canada)","funders":"","keywords":"Nerve agent; Pralidoxime; Tabun; Organophosphate poisoning; Organophosphate; Oxime; Cholinesterase; Pharmacology; Chemistry; Acetylcholinesterase; Medicine; Toxicology; Pesticide; Medicinal chemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000454152,0.0008448598,0.00135292,0.001132512,0.0002182069,0.0005732589,0.0009700698,0.0007137318,0.003651812],"category_scores_gemma":[0.0002725792,0.0002610031,0.0003815246,0.001011841,0.0003112363,0.0007031622,0.0003497466,0.001146455,0.001709057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000243669,"about_ca_system_score_gemma":0.0004310842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009136369,"about_ca_topic_score_gemma":0.001994469,"domain_scores_codex":[0.9999052,0.00001439967,0.00001269112,0.00002010507,0.00003482934,0.00001281313],"domain_scores_gemma":[0.9999046,0.0000306665,0.00002101786,0.000003924555,0.00002811039,0.000011657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001762232,0.0001904396,0.0001266599,0.008353489,0.00009948674,0.0004606511,0.00007674239,0.0005056031,0.01822857,0.00169497,0.008030111,0.962057],"study_design_scores_gemma":[0.0001343811,0.0009627953,0.001715532,0.001613225,0.000294643,0.00360988,0.00008282557,0.0003682451,0.01511886,0.00117543,0.9748811,0.00004304723],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002064599,0.9940216,0.0009052131,0.0001380353,0.0001776907,0.00002154693,0.00003584533,0.00002661724,0.002608765],"genre_scores_gemma":[0.004904773,0.9920339,0.0008682819,0.000142141,0.00009099029,0.00001269105,0.000071458,0.000003497338,0.00187229],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003651812,"threshold_uncertainty_score":0.01221651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3194645271307415,"score_gpt":0.3834390516327154,"score_spread":0.06397452450197383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}