{"id":"W2030213092","doi":"10.1534/g3.112.003780","title":"A Targeted<i>In Vivo</i>RNAi Screen Reveals Deubiquitinases as New Regulators of Notch Signaling","year":2012,"lang":"en","type":"article","venue":"G3 Genes Genomes Genetics","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; Institute of Genetics; National Institute of General Medical Sciences; National Institutes of Health; March of Dimes Foundation","keywords":"Notch signaling pathway; RNA interference; Cell biology; Hes3 signaling axis; Biology; In vivo; Signal transduction; Genetics; Gene; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001457223,0.0007511227,0.0003775517,0.000459266,0.0001831517,0.0004197217,0.000338315,0.0003616974,0.0007409832],"category_scores_gemma":[0.00008722417,0.0002342343,0.0003922098,0.000236295,0.0002361365,0.0001135835,0.0001971175,0.0003714791,0.0003937026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004195585,"about_ca_system_score_gemma":0.00017533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009727228,"about_ca_topic_score_gemma":0.002152764,"domain_scores_codex":[0.9998631,0.00001358618,0.00001629113,0.00004184881,0.00004343097,0.00002172774],"domain_scores_gemma":[0.9998792,0.00002367138,0.00004464177,0.00001394997,0.000009804746,0.00002865876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002344036,0.000008263127,0.00022886,0.00001615677,0.000006568404,0.00008333089,0.000004203562,0.00004065346,0.9989681,0.0000396755,0.00002646678,0.0005543035],"study_design_scores_gemma":[0.00001295184,0.00008895205,0.008801296,0.000005025433,0.00007023458,0.0006554389,0.00001670343,0.001033337,0.9859383,0.00003947547,0.003330418,0.000007921959],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835808,0.002046821,0.008705681,0.0001637686,0.0000299295,0.00007644881,0.002233561,0.0004242913,0.002738749],"genre_scores_gemma":[0.9836555,0.001446381,0.007345997,0.0002033459,0.00001262401,0.00003065541,0.003158038,0.0001289524,0.004018549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009727228,"threshold_uncertainty_score":0.003044128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01826566152173834,"score_gpt":0.2566369689881333,"score_spread":0.2383713074663949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}