{"id":"W2030220107","doi":"10.1634/stemcells.2008-0855","title":"Evidence for Transcriptional Regulation of the Glucose-6-Phosphate Transporter by HIF-1<i>α</i>: Targeting G6PT with Mumbaistatin Analogs in Hypoxic Mesenchymal Stromal Cells","year":2008,"lang":"en","type":"article","venue":"Stem Cells","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Jewish General Hospital; Université du Québec à Montréal","funders":"National Cancer Institute","keywords":"Biology; Aryl hydrocarbon receptor nuclear translocator; Mesenchymal stem cell; Hypoxia-inducible factors; Aryl hydrocarbon receptor; Cancer research; Cell biology; Biochemistry; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009778699,0.0002025769,0.0001391554,0.0001018138,0.00007901369,0.0001636481,0.000131525,0.0001988224,0.0008564224],"category_scores_gemma":[0.00008122322,0.00009106679,0.0001632613,0.0001109401,0.0002049764,0.00009027367,0.00008858022,0.0002799771,0.0002396933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002505771,"about_ca_system_score_gemma":0.0001403117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005184604,"about_ca_topic_score_gemma":0.0005689546,"domain_scores_codex":[0.9999276,0.00001264969,0.000006269795,0.00001708401,0.000017887,0.00001841018],"domain_scores_gemma":[0.9999151,0.0000143288,0.00003179916,0.000009119306,0.00001008653,0.00001942395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006622142,0.000006173984,0.00007932911,0.00001444316,0.000001428702,0.0000162306,0.000004514305,0.00001620297,0.9994439,0.0000426966,0.00001103602,0.0002977793],"study_design_scores_gemma":[0.00001297341,0.0001897396,0.003698001,0.000003176786,0.00000758763,0.0001673704,0.00001248069,0.0002886704,0.99424,0.00002437177,0.001354349,0.000001351452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918461,0.002208028,0.00345154,0.0001750775,0.00003078905,0.00003296187,0.0003908601,0.00007584987,0.001788761],"genre_scores_gemma":[0.9958488,0.000899112,0.00171791,0.0000955373,0.0000108291,0.00003110914,0.0004989765,0.00001797911,0.0008797435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008564224,"threshold_uncertainty_score":0.002865016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01860977265234067,"score_gpt":0.2229653043387722,"score_spread":0.2043555316864315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}