{"id":"W2030220107","doi":"10.1634/stemcells.2008-0855","title":"Evidence for Transcriptional Regulation of the Glucose-6-Phosphate Transporter by HIF-1<i>α</i>: Targeting G6PT with Mumbaistatin Analogs in Hypoxic Mesenchymal Stromal Cells","year":2008,"lang":"en","type":"article","venue":"Stem Cells","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Jewish General Hospital; Université du Québec à Montréal","funders":"National Cancer Institute","keywords":"Biology; Aryl hydrocarbon receptor nuclear translocator; Mesenchymal stem cell; Hypoxia-inducible factors; Aryl hydrocarbon receptor; Cancer research; Cell biology; Biochemistry; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002382285,0.0001906719,0.0002373545,0.00003331759,0.00009999266,0.000008733988,0.0001922062,0.0001180513,0.00002587891],"category_scores_gemma":[0.000005113858,0.0001492243,0.0001599371,0.0001568314,0.0001542023,0.00001703477,0.00001289553,0.000091141,9.923592e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001885437,"about_ca_system_score_gemma":0.0001567693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007927248,"about_ca_topic_score_gemma":0.0001263319,"domain_scores_codex":[0.9986083,0.00007205195,0.0003856062,0.0003854008,0.0002499587,0.0002986934],"domain_scores_gemma":[0.9994009,0.00003249438,0.0001805129,0.0002234612,0.000100436,0.00006217095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003722859,0.00005857203,0.00121745,0.00006428322,0.00002695545,7.695182e-7,0.0003402574,0.0003392761,0.9945365,0.000017803,0.002282095,0.0007437703],"study_design_scores_gemma":[0.001291216,0.0001919051,0.01223159,0.00007016008,0.00004197008,0.000006047447,0.00009431101,0.0001319995,0.9683297,0.0000120815,0.01740342,0.0001956503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880897,0.007263167,0.003286431,0.00007872694,0.0004490834,0.0005476011,0.0002156347,0.000006807024,0.00006282367],"genre_scores_gemma":[0.9965715,0.0008847343,0.000872572,0.00008919401,0.0002243568,0.00004305276,0.00007607191,0.00002648015,0.001211976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02620683,"threshold_uncertainty_score":0.6085189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01860977265234067,"score_gpt":0.2229653043387722,"score_spread":0.2043555316864315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}