{"id":"W2030310377","doi":"10.1371/journal.pone.0003476","title":"Stat1 Phosphorylation Determines Ras Oncogenicity by Regulating p27Kip1","year":2008,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; Canadian Breast Cancer Research Alliance","keywords":"STAT1; Phosphorylation; Carcinogenesis; Immunosurveillance; Biology; Cancer research; Tyrosine phosphorylation; Transcription factor; Cell biology; Cancer; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000777168,0.0002030808,0.0001114071,0.0003755902,0.0001995565,0.0003922416,0.0001247926,0.0001561635,0.002011974],"category_scores_gemma":[0.000151168,0.0001654222,0.0001142927,0.0001997103,0.0002798519,0.0002160229,0.0001716699,0.0002894654,0.0006973768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003721637,"about_ca_system_score_gemma":0.0002278827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007331162,"about_ca_topic_score_gemma":0.0008822801,"domain_scores_codex":[0.9999058,0.00001225276,0.00000501053,0.00001831312,0.0000207263,0.00003779646],"domain_scores_gemma":[0.9999063,0.00001428967,0.00003570781,0.000007247566,0.000009546025,0.00002686462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003835678,0.00002010048,0.003021705,0.00002133783,0.000003306966,0.0001101857,0.00002476072,0.000307971,0.9933416,0.0003008461,0.00009320684,0.002371399],"study_design_scores_gemma":[0.00002338522,0.0001509363,0.05173116,0.000007016301,0.00001271976,0.0006550518,0.00007489139,0.004097437,0.9405982,0.0004858563,0.002154458,0.000008793291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971383,0.0005360728,0.0007553424,0.00007271962,0.000007018429,0.00000479023,0.0001909511,0.00004650506,0.001248305],"genre_scores_gemma":[0.9987358,0.0002537096,0.0002123988,0.00001039876,0.000002242277,0.000002823907,0.0001378279,0.000007442134,0.0006372306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002011974,"threshold_uncertainty_score":0.006730735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07934095601781699,"score_gpt":0.2634621558213696,"score_spread":0.1841211998035526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}