{"id":"W2030314832","doi":"10.2741/1989","title":"Proteolytic enzymes in skeletal development: histochemical methods adapted to the study of matrix lysis during the transformation of a \"cartilage model\" into bone","year":2006,"lang":"en","type":"review","venue":"Frontiers in bioscience","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Cartilage; Proteases; Proteolysis; Aggrecan; Chemistry; Proteoglycan; Lysis; Biochemistry; Extracellular matrix; Cell biology; Enzyme; Pathology; Anatomy; Biology; Osteoarthritis; Medicine; Articular cartilage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00097118,0.0002587311,0.001134072,0.0005271708,0.00007428054,0.00001119077,0.0003420525,0.0001238707,0.00000191876],"category_scores_gemma":[0.00008337509,0.0001486348,0.0001565725,0.001305768,0.0001217342,0.00008493374,0.00007029315,0.0002226722,7.26028e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000378666,"about_ca_system_score_gemma":0.0002757662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003656512,"about_ca_topic_score_gemma":0.00008628336,"domain_scores_codex":[0.9977685,0.0002042623,0.000956785,0.0003450794,0.0004617416,0.0002636103],"domain_scores_gemma":[0.99924,0.00003859936,0.000264681,0.0003628054,0.00004348535,0.00005040079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009031896,0.0007433734,0.00009575121,0.005165218,0.00003964132,0.0000173128,0.01370012,0.0001012794,0.002919929,0.00006591247,0.00003690077,0.9770243],"study_design_scores_gemma":[0.04025491,0.01426338,0.0009748941,0.1277399,0.01183131,0.0004640246,0.04488055,0.02420742,0.3072443,0.001144101,0.4200324,0.006962861],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"methods","genre_scores_codex":[0.0489761,0.9274588,0.01610359,0.00006198614,0.0001976914,0.007096874,0.00001053866,0.00001936225,0.00007508625],"genre_scores_gemma":[0.2708634,0.2866403,0.4369639,0.00004009175,0.00007545819,0.004150381,0.00007838669,0.0001087056,0.001079412],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.9700614,"threshold_uncertainty_score":0.606115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02424148029326893,"score_gpt":0.3341633167999345,"score_spread":0.3099218365066655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}