{"id":"W2030314836","doi":"10.1210/en.2010-0323","title":"Involvement of RAGE, NADPH Oxidase, and Ras/Raf-1 Pathway in Glycated LDL-Induced Expression of Heat Shock Factor-1 and Plasminogen Activator Inhibitor-1 in Vascular Endothelial Cells","year":2010,"lang":"en","type":"article","venue":"Endocrinology","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; University of Manitoba; Manitoba Health Research Council; Health Sciences Centre Foundation; Canadian Diabetes Association","keywords":"Plasminogen activator inhibitor-1; NADPH oxidase; Endocrinology; Internal medicine; Plasminogen activator; Biology; Chemistry; Molecular biology; Medicine; Oxidative stress","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001242779,0.0001858702,0.000305475,0.0002106442,0.00002832187,0.000005168995,0.0001648355,0.0001949761,0.00003144862],"category_scores_gemma":[0.0002259855,0.0001773057,0.00003623596,0.0001357268,0.0001832639,0.00001441057,0.0002735866,0.0003060547,0.000001017773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001681187,"about_ca_system_score_gemma":0.0001107565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001637661,"about_ca_topic_score_gemma":0.0002228619,"domain_scores_codex":[0.9984606,0.0001507599,0.0003783451,0.0004928261,0.0001550909,0.0003623693],"domain_scores_gemma":[0.9992734,0.00006921733,0.00009539537,0.000398335,0.000080421,0.00008324419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002285534,0.0001374388,0.01066487,0.00006559862,0.00001673321,0.000009241318,0.0001839748,0.00002298322,0.9866921,0.00004107007,0.00001759957,0.001919806],"study_design_scores_gemma":[0.002155055,0.0002735291,0.01125201,0.00002075192,0.000002481836,0.000008160619,0.0001219311,0.00001133862,0.9828919,0.00005291145,0.003061609,0.0001483555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988269,0.0004165852,0.00003774157,0.00005688766,0.0001398687,0.0003962899,0.00005742621,0.000006334084,0.00006196561],"genre_scores_gemma":[0.9989327,0.0003650768,0.0004647698,0.0000231587,0.0000624189,0.0000389925,0.00003918334,0.00002144938,0.00005224533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003800262,"threshold_uncertainty_score":0.7230319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01510001710223268,"score_gpt":0.2673877671208088,"score_spread":0.2522877500185761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}