{"id":"W2030314836","doi":"10.1210/en.2010-0323","title":"Involvement of RAGE, NADPH Oxidase, and Ras/Raf-1 Pathway in Glycated LDL-Induced Expression of Heat Shock Factor-1 and Plasminogen Activator Inhibitor-1 in Vascular Endothelial Cells","year":2010,"lang":"en","type":"article","venue":"Endocrinology","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; University of Manitoba; Manitoba Health Research Council; Health Sciences Centre Foundation; Canadian Diabetes Association","keywords":"Plasminogen activator inhibitor-1; NADPH oxidase; Endocrinology; Internal medicine; Plasminogen activator; Biology; Chemistry; Molecular biology; Medicine; Oxidative stress","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001227069,0.0003749087,0.0002296385,0.0002600156,0.0002088532,0.0002206156,0.0001796162,0.000322297,0.0005648464],"category_scores_gemma":[0.00007009133,0.0001472142,0.0003511613,0.0001006973,0.0001712086,0.0002745342,0.0002064197,0.0004365798,0.0001625409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001876673,"about_ca_system_score_gemma":0.0001775834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004787002,"about_ca_topic_score_gemma":0.0004000691,"domain_scores_codex":[0.9998988,0.00002185397,0.000005981321,0.00001889149,0.00001951591,0.00003497474],"domain_scores_gemma":[0.9999621,0.000002663233,0.00001113379,0.000003025481,0.000005587449,0.00001549135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000947522,0.0001932182,0.001186463,0.0002520719,0.00003905728,0.0007174155,0.00007226838,0.00015103,0.9904737,0.0007245153,0.0001608875,0.005081805],"study_design_scores_gemma":[0.0003291703,0.001414066,0.1081668,0.00005303105,0.0001678886,0.002999446,0.0003470684,0.006827815,0.8696914,0.001422388,0.008539606,0.00004134708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810791,0.01438556,0.002074455,0.0004228468,0.00007179192,0.00004842929,0.0001911127,0.00007742521,0.001649303],"genre_scores_gemma":[0.994118,0.003268119,0.0008904558,0.0000559626,0.0000214425,0.00005160829,0.0001611367,0.000003109495,0.001430158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005648464,"threshold_uncertainty_score":0.001889586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01510001710223268,"score_gpt":0.2673877671208088,"score_spread":0.2522877500185761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}