{"id":"W2030315456","doi":"10.1210/en.2012-2226","title":"Drug Ligand-Induced Activation of Translocator Protein (TSPO) Stimulates Steroid Production by Aged Brown Norway Rat Leydig Cells","year":2013,"lang":"en","type":"article","venue":"Endocrinology","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Aging; National Institute on Deafness and Other Communication Disorders; Canadian Institutes of Health Research","keywords":"Translocator protein; Internal medicine; Endocrinology; In vivo; Leydig cell; In vitro; Ligand (biochemistry); Steroid; Mitochondrion; Biology; Cholesterol side-chain cleavage enzyme; Steroid hormone; Receptor; Chemistry; Biochemistry; Medicine; Cytochrome P450; Metabolism; Hormone; Luteinizing hormone; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008288248,0.00022477,0.0004806519,0.0001355159,0.0001073818,0.000007183152,0.00008742142,0.00007289374,0.0001040327],"category_scores_gemma":[0.0001033553,0.0001688621,0.00008698504,0.0001942671,0.0001864657,0.0001643486,0.00003717466,0.0002899282,0.000117092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004701565,"about_ca_system_score_gemma":0.00004751403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002516524,"about_ca_topic_score_gemma":0.00001216478,"domain_scores_codex":[0.9984517,0.00009342593,0.000367772,0.0005071589,0.0002034031,0.000376566],"domain_scores_gemma":[0.9991785,0.00004318219,0.0001419247,0.0003207809,0.0002447618,0.00007081204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002586485,0.0002964057,0.001037592,0.0001339815,0.0001422549,0.000004013413,0.001077898,0.000006968245,0.9855254,0.00002516152,0.003158906,0.008332793],"study_design_scores_gemma":[0.001113323,0.0005461625,0.01460328,0.00005829851,0.00004832639,0.00001699203,0.0005590969,0.000005475581,0.9811588,0.00009676445,0.001638909,0.0001546045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889855,0.0005588316,0.00002941953,0.007945652,0.0003525767,0.001644751,0.000003600775,0.00007255608,0.0004070971],"genre_scores_gemma":[0.9928604,0.00007543507,0.0001645706,0.0000610586,0.000290665,0.0001922517,0.00001689069,0.00002635946,0.006312315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01356569,"threshold_uncertainty_score":0.6885995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01501667939535511,"score_gpt":0.2440046305035269,"score_spread":0.2289879511081718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}