{"id":"W2030418851","doi":"10.1210/en.2010-1065","title":"Expression of Insulinoma-Associated 2 (INSM2) in Pancreatic Islet Cells Is Regulated by the Transcription Factors Ngn3 and NeuroD1","year":2011,"lang":"en","type":"article","venue":"Endocrinology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institutes of Health","keywords":"Islet; Biology; Pancreas; Transcription factor; Chromatin immunoprecipitation; Insulinoma; Pancreatic islets; Internal medicine; Ectopic expression; Cell biology; PAX4; Endocrinology; Molecular biology; Cancer research; Promoter; Gene expression; Gene; Homeobox; Insulin; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007847777,0.000213408,0.0001123153,0.0001521512,0.0001519206,0.0003112897,0.0000691277,0.00009435252,0.001013926],"category_scores_gemma":[0.00007244884,0.0001293203,0.0001598688,0.0001055336,0.0001992929,0.0001456781,0.0002705604,0.0002594032,0.0003069168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002681337,"about_ca_system_score_gemma":0.0001451414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003161607,"about_ca_topic_score_gemma":0.0007403691,"domain_scores_codex":[0.9999281,0.000008156563,0.000005322063,0.0000246474,0.00001799978,0.00001573387],"domain_scores_gemma":[0.9999462,0.000006635661,0.00001722171,0.000005324698,0.000004700728,0.00002001785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008549693,0.000005892102,0.000960925,0.00001402553,0.000001880295,0.00007267277,0.00001465823,0.00002046294,0.9979699,0.00009952904,0.00003179592,0.000722646],"study_design_scores_gemma":[0.00001937984,0.00009301268,0.03631598,0.00001105201,0.00001264484,0.0007084408,0.00009974313,0.0009798856,0.9559129,0.000134168,0.005706805,0.000005953649],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943751,0.00126872,0.002220623,0.00006875908,0.00002282332,0.000006626097,0.0002979393,0.00005611691,0.001683244],"genre_scores_gemma":[0.9928632,0.0007901513,0.002013898,0.00004097154,0.000009522385,0.00001140722,0.000730629,0.00002201838,0.003518384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001013926,"threshold_uncertainty_score":0.003391922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02658175424432376,"score_gpt":0.2280183700955576,"score_spread":0.2014366158512338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}