{"id":"W2030420318","doi":"10.1038/nmeth1131","title":"Prion strain discrimination using luminescent conjugated polymers","year":2007,"lang":"en","type":"article","venue":"Nature Methods","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":277,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"National Institute of Allergy and Infectious Diseases; European Commission","keywords":"Scrapie; Chronic wasting disease; Bovine spongiform encephalopathy; Prion protein; Transmissible spongiform encephalopathy; Fibril; Strain (injury); Conjugated system; Biology; Virology; Recombinant DNA; Biophysics; Chemistry; Polymer; Biochemistry; Disease; Gene; Pathology; Medicine; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009099733,0.0006512552,0.0002577679,0.0005134678,0.0002629606,0.001014846,0.0005632916,0.0009503216,0.00135783],"category_scores_gemma":[0.0009807831,0.0004433566,0.0002360739,0.0002786743,0.0004488261,0.0007945009,0.000531721,0.001279144,0.0006582324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000391753,"about_ca_system_score_gemma":0.0001633482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008195073,"about_ca_topic_score_gemma":0.0002050998,"domain_scores_codex":[0.9995352,0.0001312132,0.00002349445,0.0001360261,0.0001081209,0.00006602908],"domain_scores_gemma":[0.999285,0.000353588,0.0001300461,0.00007262925,0.00006932043,0.00008938272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001523802,0.00005573787,0.000221867,0.00004793869,0.000006043826,0.00006161317,0.00002674046,0.0001219572,0.992777,0.0008172658,0.0001245876,0.005586903],"study_design_scores_gemma":[0.00001354507,0.000081719,0.0003267083,0.000006103255,0.000006137652,0.0001150083,0.000006958048,0.001559513,0.9968653,0.0001684879,0.0008426019,0.00000790624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9013805,0.001743093,0.08882873,0.00044518,0.0001527098,0.00009492948,0.0001602318,0.0004804756,0.006714121],"genre_scores_gemma":[0.9463484,0.00119454,0.04395194,0.0003520646,0.00005183933,0.0001126662,0.0003498921,0.0001277548,0.007510756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00135783,"threshold_uncertainty_score":0.004812419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01964901693973578,"score_gpt":0.3941667120779223,"score_spread":0.3745176951381864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}