{"id":"W2030420318","doi":"10.1038/nmeth1131","title":"Prion strain discrimination using luminescent conjugated polymers","year":2007,"lang":"en","type":"article","venue":"Nature Methods","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":277,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"National Institute of Allergy and Infectious Diseases; European Commission","keywords":"Scrapie; Chronic wasting disease; Bovine spongiform encephalopathy; Prion protein; Transmissible spongiform encephalopathy; Fibril; Strain (injury); Conjugated system; Biology; Virology; Recombinant DNA; Biophysics; Chemistry; Polymer; Biochemistry; Disease; Gene; Pathology; Medicine; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001020556,0.0001314465,0.0001037745,0.00006092697,0.00008384525,0.00002089065,0.0001204251,0.0003561732,0.00004304974],"category_scores_gemma":[0.0002955152,0.0001220883,0.0000910537,0.0001337766,0.00003905375,0.000004467206,0.00005992307,0.000199759,7.98357e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002865106,"about_ca_system_score_gemma":0.00004799535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009970253,"about_ca_topic_score_gemma":0.00000759173,"domain_scores_codex":[0.9990278,0.0001595012,0.0001747405,0.0002729726,0.0001270539,0.0002378661],"domain_scores_gemma":[0.9995003,0.00002354248,0.00008588901,0.0002123138,0.00007475028,0.0001031577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006830447,0.00001918475,0.0001730592,0.00001327487,0.0000168447,0.000002671154,0.00001826516,0.000006735999,0.7335957,0.0001457753,0.00004935541,0.2658909],"study_design_scores_gemma":[0.0003966879,0.00006872101,0.00436985,0.00002469256,0.00003847329,0.00001464507,0.0001118153,0.0003127171,0.9579817,0.0001421806,0.03632087,0.0002176597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.522179,0.02387002,0.4519721,0.0002160857,0.0007033514,0.0003333369,0.00002722756,0.00003303383,0.0006658772],"genre_scores_gemma":[0.8359393,0.0002170813,0.1626065,0.0005400429,0.0003687351,0.000002887375,0.0001571474,0.00002438338,0.0001439018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3137604,"threshold_uncertainty_score":0.4978617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01964901693973578,"score_gpt":0.3941667120779223,"score_spread":0.3745176951381864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}