{"id":"W2030434576","doi":"10.1038/sj.mt.6300242","title":"Uncoating Reo: Uncovering the Steps Critical for Oncolysis","year":2007,"lang":"en","type":"letter","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; Université de Montréal","funders":"","keywords":"Oncolytic virus; Biology; Virology; Permissiveness; Viral replication; Effector; Vesicular stomatitis virus; Reoviridae; Virotherapy; Cell culture; Virus; Cytopathic effect; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001207354,0.0005740878,0.0004446314,0.0001416393,0.0003434052,0.0001666281,0.001069717,0.001095979,0.00007132995],"category_scores_gemma":[0.0003031341,0.0004546949,0.0006654706,0.0002516947,0.0002869089,0.000004345746,0.0001664077,0.00117173,0.00002635498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009509298,"about_ca_system_score_gemma":0.0003067704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002887587,"about_ca_topic_score_gemma":0.00004065084,"domain_scores_codex":[0.9963589,0.0004114246,0.0004746164,0.000950678,0.0007491774,0.001055252],"domain_scores_gemma":[0.9976258,0.000284686,0.00015524,0.001478187,0.0003543492,0.0001017373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001588116,0.00005958722,0.00001262058,0.00008737543,0.0006228244,0.0001756317,0.00005205915,0.0001424431,0.6957728,0.00001745875,0.2809496,0.02051949],"study_design_scores_gemma":[0.0006920465,0.001630162,0.000002219374,0.00002622553,0.00003268035,0.00001516427,0.00001861597,0.00002599657,0.3794862,0.0002321349,0.6174438,0.000394718],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.2123189,0.03079269,0.07433634,0.671446,0.001788939,0.005601616,0.0004335758,0.0001853046,0.003096663],"genre_scores_gemma":[0.0223766,0.001047081,0.002206919,0.9612816,0.007377761,0.0007556854,0.00131212,0.0005346494,0.003107587],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.3364943,"threshold_uncertainty_score":0.9997905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03220333585724271,"score_gpt":0.348998068414933,"score_spread":0.3167947325576903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}