{"id":"W2030444172","doi":"10.1038/ncomms1204","title":"Structural basis for the recognition and cleavage of histone H3 by cathepsin L","year":2011,"lang":"en","type":"article","venue":"Nature Communications","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Shriners Hospitals for Children - Canada; Structural Genomics Consortium; University of Toronto","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; Ontario Innovation Trust; Wellcome Trust; GlaxoSmithKline","keywords":"Histone H3; Cathepsin O; Histone; Cathepsin A; Histone H2A; Cathepsin E; Cell biology; Histone methyltransferase; Biochemistry; Histone code; Biology; Chemistry; Cathepsin B; Molecular biology; Enzyme; Nucleosome; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001341823,0.0003597382,0.000278973,0.0001278591,0.0003309996,0.0005641521,0.0006873001,0.0006469881,0.001158573],"category_scores_gemma":[0.0002517202,0.0002037409,0.0004805296,0.0001354464,0.0004096085,0.000277345,0.0003244167,0.0005818562,0.000557778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008128068,"about_ca_system_score_gemma":0.0004744016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001773399,"about_ca_topic_score_gemma":0.001062378,"domain_scores_codex":[0.999891,0.00001470353,0.000008380362,0.0000199513,0.00003446463,0.00003153325],"domain_scores_gemma":[0.9998748,0.00001689567,0.00004011303,0.00001124882,0.00001434319,0.00004259399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006553817,0.0001319186,0.002608414,0.0001563114,0.00004453434,0.002007007,0.000111163,0.002354973,0.984674,0.004166384,0.0004080725,0.002681957],"study_design_scores_gemma":[0.0004059037,0.0006298312,0.02600545,0.00003323787,0.00006648148,0.003546,0.0002106934,0.01987396,0.9371997,0.003130988,0.008835018,0.00006276333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990148,0.001497814,0.00418047,0.0005053485,0.00006004909,0.00003645455,0.0002084326,0.0001067676,0.003256752],"genre_scores_gemma":[0.9971138,0.0003533865,0.001399913,0.0001017164,0.00001018676,0.00001112513,0.0002707377,0.000008908959,0.000730185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001773399,"threshold_uncertainty_score":0.005897403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0398830113352649,"score_gpt":0.300674998659161,"score_spread":0.2607919873238961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}