{"id":"W2030444172","doi":"10.1038/ncomms1204","title":"Structural basis for the recognition and cleavage of histone H3 by cathepsin L","year":2011,"lang":"en","type":"article","venue":"Nature Communications","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Shriners Hospitals for Children - Canada; Structural Genomics Consortium; University of Toronto","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; Ontario Innovation Trust; Wellcome Trust; GlaxoSmithKline","keywords":"Histone H3; Cathepsin O; Histone; Cathepsin A; Histone H2A; Cathepsin E; Cell biology; Histone methyltransferase; Biochemistry; Histone code; Biology; Chemistry; Cathepsin B; Molecular biology; Enzyme; Nucleosome; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009879052,0.00005312744,0.0000510692,0.00001155723,0.0001320887,0.000003919125,0.0002777081,0.0001407129,0.000005103431],"category_scores_gemma":[0.00009031099,0.0000401933,0.00003627601,0.00003181686,0.00009453589,0.000003263307,0.0001033485,0.0001237578,6.324167e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004714657,"about_ca_system_score_gemma":0.00001470075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003666633,"about_ca_topic_score_gemma":0.00007122489,"domain_scores_codex":[0.9996971,0.00003539992,0.00008872924,0.00008586072,0.00003241476,0.00006051272],"domain_scores_gemma":[0.9992332,0.00003220912,0.00006171981,0.0005813346,0.00007256856,0.00001891014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005000702,0.00003893655,0.00006858191,0.000008537421,0.00004033602,2.28906e-8,0.0002210485,2.11781e-8,0.9758455,0.001150854,0.01484775,0.007728437],"study_design_scores_gemma":[0.0001623484,0.00009776092,0.0003659819,0.000007445808,0.00003525531,0.000002858561,0.00008644607,0.0000274259,0.9768118,0.001104598,0.02123096,0.00006711905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8893037,0.09717476,0.002571867,0.002368843,0.0003702859,0.001517651,0.001433081,0.00003306683,0.005226759],"genre_scores_gemma":[0.9933693,0.0008360592,0.005145987,0.0002298178,0.00002595136,0.00005456897,0.0002641786,0.000007760328,0.00006638967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1040656,"threshold_uncertainty_score":0.1639035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0398830113352649,"score_gpt":0.300674998659161,"score_spread":0.2607919873238961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}