{"id":"W2030470971","doi":"10.1097/fjc.0b013e3181e23e10","title":"Pharmacological Inhibition of Cathepsin S Decreases Atherosclerotic Lesions in Apoe-/- Mice","year":2010,"lang":"en","type":"article","venue":"Journal of Cardiovascular Pharmacology","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada); University of British Columbia","funders":"Canadian Institutes of Health Research; Merck","keywords":"Cathepsin; Elastin; Cathepsin K; Cathepsin S; Cathepsin L; Cathepsin D; Apolipoprotein E; Spleen; Cathepsin B; Extracellular matrix; Internal elastic lamina; Medicine; In vivo; Endocrinology; Internal medicine; Pathology; Chemistry; Artery; Biology; Enzyme; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003256357,0.0009165582,0.0006640751,0.000806223,0.0001956687,0.0004194042,0.0002946308,0.0005417304,0.001459786],"category_scores_gemma":[0.0002691564,0.0002870855,0.0003705877,0.0002111666,0.0003965941,0.0002266054,0.000183584,0.0007845261,0.0004581782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002801639,"about_ca_system_score_gemma":0.0002693138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006277849,"about_ca_topic_score_gemma":0.0009970166,"domain_scores_codex":[0.9997343,0.00005828901,0.00003048761,0.00004992232,0.00006328546,0.00006367642],"domain_scores_gemma":[0.9996467,0.00004123133,0.0001413839,0.00003329672,0.00003048645,0.0001069198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007385329,0.0001452193,0.0002722165,0.00003247373,0.00001608442,0.00005231,0.00001074183,0.0000321354,0.9972222,0.00005789449,0.00003857557,0.001381554],"study_design_scores_gemma":[0.0002299929,0.003094261,0.008668323,0.00001924495,0.00008775003,0.0005537464,0.00003876769,0.000737541,0.9843391,0.00009029236,0.002128894,0.00001199911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933608,0.002036429,0.002608107,0.0002676335,0.00004496169,0.00004103635,0.0004135507,0.0002297861,0.0009976395],"genre_scores_gemma":[0.9870363,0.002951674,0.00422623,0.0001661427,0.00006564902,0.0001097353,0.0008167882,0.00009922326,0.004528224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001459786,"threshold_uncertainty_score":0.004883468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01349547440152575,"score_gpt":0.2683589944469146,"score_spread":0.2548635200453888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}