{"id":"W2030479182","doi":"10.1073/pnas.0803678105","title":"Protein histidine phosphatase 1 negatively regulates CD4 T cells by inhibiting the K <sup>+</sup> channel KCa3.1","year":2008,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Mechanisms of cancer metastasis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Karolinska Institutet; York University","keywords":"Dephosphorylation; Phosphatase; Histidine; Phosphorylation; Jurkat cells; T-cell receptor; Cell biology; Biology; Signal transduction; Kinase; Protein kinase A; Biochemistry; Molecular biology; Enzyme; Chemistry; T cell; Immunology; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001144124,0.0002706476,0.0001444029,0.0001372062,0.0001338221,0.0003112119,0.0001618141,0.0001874693,0.00111796],"category_scores_gemma":[0.0001348555,0.00009744667,0.0001230321,0.00009342578,0.0003126772,0.0001287998,0.0001727245,0.0005059089,0.0003535008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004174409,"about_ca_system_score_gemma":0.0002175934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004518254,"about_ca_topic_score_gemma":0.0006373154,"domain_scores_codex":[0.9998889,0.00001797807,0.000006735511,0.00002083441,0.00003039929,0.00003503004],"domain_scores_gemma":[0.9999303,0.00001320756,0.00002091509,0.000005276378,0.000008519474,0.00002192741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001182642,0.00001867443,0.0002314212,0.00002396263,0.000003190063,0.00004622707,0.000005844471,0.00008763492,0.9976568,0.0002175328,0.0001241869,0.001466251],"study_design_scores_gemma":[0.00003190523,0.0001230439,0.004546363,0.000003085387,0.00001069125,0.0002065802,0.00001983347,0.001727474,0.9900635,0.0001413532,0.003123613,0.000002580943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905991,0.003036458,0.002406134,0.0003792463,0.00007095632,0.00002051213,0.000208786,0.0001534697,0.003125364],"genre_scores_gemma":[0.9956513,0.0007694092,0.0009451571,0.00008859609,0.00001320259,0.00001828183,0.0001550601,0.00001924379,0.002339799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00111796,"threshold_uncertainty_score":0.003740013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02780881373170827,"score_gpt":0.2603974662598467,"score_spread":0.2325886525281384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}