{"id":"W2030502071","doi":"10.2217/fvl.13.130","title":"Biophysical Approaches to Entry Inhibitor Antivirals with a Broad Spectrum of Action","year":2014,"lang":"en","type":"article","venue":"Future Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Burroughs Wellcome Fund","keywords":"Infectivity; Small molecule; Viral envelope; Drug discovery; Antiviral drug; Drug development; Envelope (radar); In vivo; Drug; Broad spectrum; Computational biology; Biology; Viral entry; Chemistry; Virology; Cell biology; Virus; Biochemistry; Viral replication; Pharmacology; Computer science; Genetics; Combinatorial chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005160373,0.0006200706,0.0005054267,0.0005586513,0.0003403375,0.0007007572,0.0005011196,0.0007429166,0.003010319],"category_scores_gemma":[0.0003834559,0.0004444632,0.0005699554,0.0002619587,0.0006119556,0.0008735516,0.0007138175,0.00234689,0.001332683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007188935,"about_ca_system_score_gemma":0.0004570889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002688566,"about_ca_topic_score_gemma":0.0004885279,"domain_scores_codex":[0.9997153,0.00006942267,0.00001695843,0.00004529481,0.00009921367,0.00005377045],"domain_scores_gemma":[0.9998197,0.00005198901,0.00003932331,0.00002439871,0.00003494984,0.00002970814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001324488,0.0002534895,0.00009212389,0.0002956414,0.00001903744,0.00009240246,0.00004658578,0.0006051069,0.9679358,0.008068793,0.0005399486,0.02191853],"study_design_scores_gemma":[0.0001413175,0.001496871,0.0006795346,0.00007216702,0.00004871274,0.0005122962,0.00006476306,0.002929276,0.9215,0.003996256,0.06852283,0.0000361079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3928976,0.1225966,0.4134198,0.007604812,0.001831509,0.001297719,0.000616129,0.001582558,0.05815322],"genre_scores_gemma":[0.7999137,0.0734273,0.09290785,0.003276793,0.0005586558,0.001176411,0.0005037417,0.0002113552,0.02802415],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003010319,"threshold_uncertainty_score":0.01007056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02370521199511699,"score_gpt":0.2235527515539574,"score_spread":0.1998475395588404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}