{"id":"W2030502071","doi":"10.2217/fvl.13.130","title":"Biophysical Approaches to Entry Inhibitor Antivirals with a Broad Spectrum of Action","year":2014,"lang":"en","type":"article","venue":"Future Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Burroughs Wellcome Fund","keywords":"Infectivity; Small molecule; Viral envelope; Drug discovery; Antiviral drug; Drug development; Envelope (radar); In vivo; Drug; Broad spectrum; Computational biology; Biology; Viral entry; Chemistry; Virology; Cell biology; Virus; Biochemistry; Viral replication; Pharmacology; Computer science; Genetics; Combinatorial chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001222774,0.0001733506,0.0003615489,0.0001517561,0.00006664071,0.000005142899,0.0001585309,0.0002892273,0.0002153399],"category_scores_gemma":[0.00002562882,0.0001251355,0.00007487373,0.000133011,0.0002184602,0.00005007265,0.00006558833,0.0002673247,0.0004684964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001485909,"about_ca_system_score_gemma":0.00002573131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002473465,"about_ca_topic_score_gemma":0.00002894817,"domain_scores_codex":[0.9988421,0.0003389743,0.0001984118,0.0002791208,0.00002763688,0.0003137563],"domain_scores_gemma":[0.9995115,0.00007964212,0.00009636751,0.0002750407,0.0000171576,0.00002028968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003328252,0.0001936913,0.0005040122,0.00001726535,0.0001155849,0.00000139126,0.0003367797,0.000002772239,0.9812437,0.00618611,0.003066472,0.005003964],"study_design_scores_gemma":[0.0009898808,0.002699829,0.01664835,0.00001545259,0.00003279302,0.00008059377,0.0002220232,0.000004657271,0.8289887,0.00006392248,0.1500961,0.0001577049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935015,0.000230178,0.0009071381,0.002516192,0.0009894214,0.0001786873,0.00001281039,0.00004906961,0.001615004],"genre_scores_gemma":[0.9972156,0.00001553482,0.0001057801,0.0003713807,0.0003524513,0.00001605996,0.00003007974,0.00001630202,0.001876782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.152255,"threshold_uncertainty_score":0.602173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02370521199511699,"score_gpt":0.2235527515539574,"score_spread":0.1998475395588404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}