{"id":"W2030568706","doi":"10.1110/ps.062112106","title":"Structural analysis of an “open” form of PBP1B from <i>Streptococcus pneumoniae</i>","year":2006,"lang":"en","type":"article","venue":"Protein Science","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canadian Blood Services","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Peptidoglycan; Active site; Stereochemistry; Chemistry; Context (archaeology); Enzyme; Acylation; Glycosyltransferase; Biochemistry; Hydrolase; Biology; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001017058,0.0003171814,0.0002810179,0.0001642681,0.0002727586,0.0003232968,0.0004202468,0.0003721391,0.0007898704],"category_scores_gemma":[0.0002798743,0.0001539289,0.0002328815,0.000271021,0.0003009048,0.0001966043,0.000166237,0.0006758152,0.0002149884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005891321,"about_ca_system_score_gemma":0.0003087134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003276156,"about_ca_topic_score_gemma":0.002871034,"domain_scores_codex":[0.9999321,0.000009222769,0.000003232807,0.00001267963,0.00002928615,0.00001345243],"domain_scores_gemma":[0.9998817,0.00002448605,0.00003134921,0.000005599973,0.00001709488,0.00003979796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009348874,0.0001775939,0.002561409,0.0002543308,0.0000432194,0.001596491,0.0002686433,0.00165253,0.9847969,0.0007683342,0.0007305895,0.006215233],"study_design_scores_gemma":[0.0004010222,0.001813857,0.1014058,0.0001371419,0.0002722093,0.009589479,0.001032346,0.02623622,0.826512,0.001054238,0.03141336,0.0001324462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969351,0.001057836,0.000607055,0.0001482033,0.00001574897,0.000007895755,0.0003836717,0.00002566506,0.0008188372],"genre_scores_gemma":[0.9930531,0.0007453489,0.002153885,0.00007782284,0.00001208538,0.000009947131,0.003071678,0.00002108199,0.0008549702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003276156,"threshold_uncertainty_score":0.006514192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01654310627641868,"score_gpt":0.3036236429789774,"score_spread":0.2870805367025587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}