{"id":"W2030581432","doi":"10.1038/nature11013","title":"Systematic discovery of structural elements governing stability of mammalian messenger RNAs","year":2012,"lang":"en","type":"article","venue":"Nature","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":208,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Environmental Health Sciences; National Human Genome Research Institute; National Institute of General Medical Sciences; National Institute on Drug Abuse; National Institutes of Health","keywords":"Computational biology; RNA; RNA splicing; Biology; RNA-binding protein; Nucleic acid secondary structure; Genetics; Translation (biology); Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004099925,0.0002141432,0.0003157402,0.0003050353,0.0003546877,0.0004584381,0.0003912796,0.0003496688,0.000316991],"category_scores_gemma":[0.000646801,0.0003190716,0.0002171403,0.000259266,0.0004624532,0.0002207417,0.0002513948,0.0006573259,0.0001188697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000341284,"about_ca_system_score_gemma":0.0004810567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002909018,"about_ca_topic_score_gemma":0.0009199357,"domain_scores_codex":[0.9998775,0.0000220291,0.00001281669,0.00002581175,0.00004171783,0.0000200486],"domain_scores_gemma":[0.9995944,0.0002031772,0.00008397855,0.00006449594,0.00002929335,0.00002460001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008356883,0.00001365381,0.000344966,0.00002967439,0.000004511354,0.00005178357,0.00001970635,0.0002542043,0.9955679,0.0008343293,0.00002917093,0.002766533],"study_design_scores_gemma":[0.00001914967,0.0001489134,0.003239754,0.000005935143,0.00002876609,0.0002343104,0.00002434973,0.001703423,0.9919104,0.000774319,0.001902897,0.000007813049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881485,0.00112997,0.009178817,0.0001043098,0.00002116479,0.0000337839,0.0002326923,0.00008247128,0.001068252],"genre_scores_gemma":[0.9885795,0.0007701322,0.009617339,0.00007594657,0.00002051779,0.00002405604,0.0004330614,0.00004962921,0.0004297415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004584381,"threshold_uncertainty_score":0.002476156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007753576117019031,"score_gpt":0.2492715252526403,"score_spread":0.2415179491356213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}