{"id":"W2030581432","doi":"10.1038/nature11013","title":"Systematic discovery of structural elements governing stability of mammalian messenger RNAs","year":2012,"lang":"en","type":"article","venue":"Nature","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":208,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Environmental Health Sciences; National Human Genome Research Institute; National Institute of General Medical Sciences; National Institute on Drug Abuse; National Institutes of Health","keywords":"Computational biology; RNA; RNA splicing; Biology; RNA-binding protein; Nucleic acid secondary structure; Genetics; Translation (biology); Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003795728,0.0001070973,0.0002186589,0.00001510874,0.00002243074,0.000006108128,0.0001553629,0.0004636841,0.00004191886],"category_scores_gemma":[0.0002239423,0.00008109865,0.00009940845,0.00004387591,0.00002815311,0.00001083946,0.00006468984,0.0001903318,0.000001406763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001059487,"about_ca_system_score_gemma":0.00002076304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006566042,"about_ca_topic_score_gemma":0.000004782541,"domain_scores_codex":[0.9991063,0.0001110976,0.0002784621,0.0001311268,0.0002064683,0.0001665739],"domain_scores_gemma":[0.9993584,0.00001852036,0.0002098645,0.000315609,0.0000606447,0.00003700286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003965858,0.00002043878,0.008304257,0.002341888,0.00006603198,1.696509e-7,0.00006704214,7.222401e-7,0.9887046,0.0003531353,0.00004062193,0.00006143012],"study_design_scores_gemma":[0.0001328245,0.00005300788,0.005596517,0.0002062432,0.00003557927,0.000002866446,0.0001567936,0.000002949069,0.9935393,0.00003640581,0.0001493913,0.0000880732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994249,0.004775453,0.0001726249,0.00001675038,0.0002308032,0.0002376797,0.00006499614,0.000002808455,0.0002498269],"genre_scores_gemma":[0.9988397,0.00001365439,0.0008159952,0.00003225173,0.00009668227,0.000009016241,0.00003043305,0.00001120238,0.0001510475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004834745,"threshold_uncertainty_score":0.3576357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007753576117019031,"score_gpt":0.2492715252526403,"score_spread":0.2415179491356213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}