{"id":"W2030592653","doi":"10.1517/14728222.2013.812074","title":"CCN2: a novel, specific and valid target for anti-fibrotic drug intervention","year":2013,"lang":"en","type":"review","venue":"Expert Opinion on Therapeutic Targets","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Matricellular protein; CTGF; Fibrosis; Growth factor; Connective tissue; Cancer research; Biology; Medicine; Cell biology; Immunology; Extracellular matrix; Pathology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005434054,0.0006766746,0.00102364,0.0009562502,0.0002447169,0.0007541767,0.0006478,0.00134111,0.004734789],"category_scores_gemma":[0.0004760367,0.0001866352,0.0003976336,0.0007905769,0.0004906728,0.001113725,0.0004992225,0.002133955,0.00327946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006708436,"about_ca_system_score_gemma":0.0008504194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005708895,"about_ca_topic_score_gemma":0.001313226,"domain_scores_codex":[0.9998252,0.00002944786,0.00001447018,0.00003628808,0.00007359532,0.00002116277],"domain_scores_gemma":[0.9997969,0.00006442878,0.00003040708,0.000006711527,0.00007501132,0.00002659693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009733305,0.00005645946,0.0001182856,0.01250127,0.000073823,0.0003293132,0.00004152837,0.0002855865,0.009373394,0.009077103,0.08144457,0.8866013],"study_design_scores_gemma":[0.00002535557,0.00007483319,0.0003209391,0.001543592,0.00004466074,0.001075535,0.00002436267,0.0001239174,0.001291767,0.001959452,0.9934999,0.00001575813],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002134563,0.9942653,0.0005660542,0.001673036,0.0009006442,0.00001434069,0.00005536035,0.0000186548,0.002293187],"genre_scores_gemma":[0.001889471,0.9939891,0.0005570346,0.0009363075,0.0006104971,0.00002168724,0.00009997014,0.000003836862,0.001892064],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004734789,"threshold_uncertainty_score":0.01583946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1063405685011967,"score_gpt":0.4031384518948709,"score_spread":0.2967978833936742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}